Na-Na Zhang

TL;DR: This model provides evidence for a direct link between Zika virus infection and microcephaly, with potential for further exploration of the underlying mechanisms and management of ZIKV-related pathological effects during brain development.

TL;DR: It is demonstrated that cholesterol‐25‐hydroxylase (CH25H) was induced in response to ZikV infection and that its enzymatic product, 25‐hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV.

TL;DR: The dataset has now been submitted to the Genome Sequence Archive of the Beijing Institute of Genomics Data Center under the accession number PRJCA000267 and the online version of the paper has been modified to include an Accession Numbers section.

TL;DR: It is shown that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs, but not in the more differentiated progenies or somatic cells, and enoxacin, a broad-spectrum antibiotic that is known as an RNAi enhancer, exerts potent anti-ZIKV activity in hnPCs and other RNAi-competent cells.

TL;DR: Intraperitoneal administration of Z2 inhibits vertical transmission of ZIKV in pregnant C57BL/6 mice and protects type I or type I/II interferon receptor-deficient mice against lethal ZikV challenge, and has potential to be further developed as an antiviral treatment in high-risk populations, particularly pregnant women.