G
Guan Yang
Researcher at Protein Sciences
Publications - 46
Citations - 3426
Guan Yang is an academic researcher from Protein Sciences. The author has contributed to research in topics: Cellular differentiation & PTEN. The author has an hindex of 21, co-authored 39 publications receiving 2348 citations.
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Journal ArticleDOI
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy.
Hongjing Gu,Qi Chen,Guan Yang,Lei He,Hang Fan,Yong Qiang Deng,Yanxiao Wang,Yue Teng,Zhongpeng Zhao,Yujun Cui,Li Yuchang,Xiaofeng Li,Jiangfan Li,Na Na Zhang,Xiaolan Yang,Shaolong Chen,Yan Guo,Guangyu Zhao,Xiliang Wang,De Yan Luo,Hui Wang,Xiao Yang,Yan Li,Gencheng Han,Yuxian He,Xiaojun Zhou,Shusheng Geng,Xiaoli Sheng,Shibo Jiang,Shihui Sun,Cheng-Feng Qin,Yusen Zhou +31 more
TL;DR: A mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia is developed, and a panel of adaptive mutations potentially associated with the increased virulence are revealed.
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A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
Shi Hui Sun,Qi Chen,Hong Jing Gu,Guan Yang,Yan Xiao Wang,Xing Yao Huang,Su Su Liu,Na Na Zhang,Xiaofeng Li,Rui Xiong,Yan Guo,Yong Qiang Deng,Weijin Huang,Quan Liu,Quan Ming Liu,Yue Lei Shen,Yong Zhou,Xiao Yang,Tong Yan Zhao,Chang Fa Fan,Yu Sen Zhou,Cheng-Feng Qin,You Chun Wang +22 more
TL;DR: This animal model, generated using CRISPR/Cas9 knock-in technology, provides a useful tool for studying SARS-CoV-2 transmission and pathogenesis, and evaluating COVID-19 vaccines and therapeutics.
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A Thermostable mRNA Vaccine against COVID-19.
Na Na Zhang,Xiaofeng Li,Yong Qiang Deng,Hui Zhao,Yi Jiao Huang,Guan Yang,Weijin Huang,Peng Gao,Chao Zhou,Rong Rong Zhang,Yan Guo,Shi Hui Sun,Hang Fan,Shu Long Zu,Qi Chen,Qi He,Tian Shu Cao,Xing Yao Huang,Hong Ying Qiu,Jian Hui Nie,Yuhang Jiang,Hua Yuan Yan,Qing Ye,Xia Zhong,Xia Lin Xue,Zhen Yu Zha,Dongsheng Zhou,Xiao Yang,You Chun Wang,Bo Ying,Cheng-Feng Qin +30 more
TL;DR: A lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (termed ARCoV) is developed and is currently being evaluated in phase 1 clinical trials.
Journal ArticleDOI
Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch.
Fangfei Li,Yu Lan,Youliang Wang,Jun Wang,Guan Yang,Fanwei Meng,Hua Han,Anming Meng,Yaping Wang,Xiao Yang +9 more
TL;DR: It is reported that disruption of Smad4, the central intracellular mediator of transforming growth factor-β (TGF-β) signaling, specifically in the cerebral ECs, results in perinatal ICH and blood-brain barrier breakdown and suggest important implications for genetic or functional deficiencies in TGF- β/Smad signaling in the pathogenesis of cerebrovascular dysfunction.
Journal ArticleDOI
The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy
Lantao Liu,Xiangbo An,Zhenhua Li,Yao Song,Linling Li,Song Zuo,Nian Liu,Guan Yang,Haijing Wang,Xuan Cheng,Youyi Zhang,Xiao Yang,Jing Wang +12 more
TL;DR: Findings reveal a novel function of H19-miR-675 axis targeting CaMKIIδ as a negative regulator of cardiac hypertrophy, suggesting its potential therapeutic role in cardiac diseases.