G
Georg Emons
Researcher at University of Göttingen
Publications - 21
Citations - 1018
Georg Emons is an academic researcher from University of Göttingen. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 10, co-authored 19 publications receiving 843 citations.
Papers
More filters
Journal ArticleDOI
Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
Jochen Gaedcke,Marian Grade,Klaus Jung,Jordi Camps,Peter Jo,Georg Emons,Anastasia Gehoff,Ulrich Sax,Markus D. Schirmer,Heinz Becker,Tim Beissbarth,Thomas Ried,B. Michael Ghadimi +12 more
TL;DR: Findings suggest a potential approach to overcome resistance to treatment with antibodies against the epithelial growth factor receptor in patients with KRAS‐mutant rectal carcinomas.
Journal ArticleDOI
Impact of RNA degradation on gene expression profiling
Lennart Opitz,Gabriela Salinas-Riester,Marian Grade,Klaus Jung,Peter Jo,Georg Emons,B. Michael Ghadimi,Tim Beißbarth,Jochen Gaedcke +8 more
TL;DR: Degraded RNA from tumor samples (RIN > 5) can still be used to perform gene expression analysis, but there are genes, very short ones and those with the probe binding side close to the 5' end that should be excluded from gene expressionAnalysis when working with degraded RNA.
Journal ArticleDOI
STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo
Melanie Spitzner,Birte Roesler,Christian Bielfeld,Georg Emons,Jochen Gaedcke,Hendrik A. Wolff,Margret Rave-Fränk,Frank Kramer,Tim Beissbarth,Julia Kitz,Jürgen Wienands,B. Michael Ghadimi,Reinhard Ebner,Thomas Ried,Marian Grade +14 more
TL;DR: Results highlight a potential role of STAT3 in mediating treatment resistance and provide first proof of concept that STAT3 represents a promising novel molecular target for sensitizing resistant rectal cancers to CT/RT.
Journal ArticleDOI
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.
Georg Emons,Melanie Spitzner,Sebastian Reineke,Janneke Möller,Noam Auslander,Frank Kramer,Yue Hu,Tim Beissbarth,Hendrik A. Wolff,Margret Rave-Fränk,Elisabeth Heßmann,Jochen Gaedcke,B. Michael Ghadimi,Steven A. Johnsen,Thomas Ried,Marian Grade +15 more
TL;DR: Aberrant activation of Wnt/β-catenin signaling not only regulates the development and progression of colorectal cancer, but also mediates resistance of rectal cancers to chemoradiotherapy.
Journal ArticleDOI
Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy
Emil Kendziorra,Kerstin Ahlborn,Melanie Spitzner,Margret Rave-Fränk,Georg Emons,Jochen Gaedcke,Frank Kramer,Hendrik A. Wolff,Heinz Becker,Tim Beissbarth,Reinhard Ebner,B. Michael Ghadimi,Tobias Pukrop,Thomas Ried,Marian Grade +14 more
TL;DR: Results suggest that TCF4 is a promising molecular target to sensitize resistant tumor cells to (chemo-) radiotherapy, and indicate a novel mechanism through which the Wnt transcription factor TCF 4 mediates chemoradioresistance.