Georg Juckel

TL;DR: A differential predictive clinical model of transition to first-episode psychosis is developed that identified an increased risk of psychosis with appropriate prognostic accuracy in a sample of help-seeking patients.

TL;DR: In unmedicated schizophrenic patients, a high striatal dopamine turnover may increase the "noise" in the reward system, thus interfering with the neuronal processing of reward-predicting cues by phasic dopamine release, which may contribute to negative symptoms as such as anhedonia, apathy, and loss of drive and motivation.

TL;DR: The results suggest that mesolimbic activation in alcoholics is biased towards processing of alcohol cues, which might explain why alcoholics find it particularly difficult to focus on conventional reward cues and engage in alternative rewarding activities.

TL;DR: Functional magnetic resonance imaging was used to assess the blood oxygen level dependency response in the ventral striatum of medicated schizophrenics and healthy control subjects during reward anticipation to reflect the improved efficacy of these drugs in treating negative symptoms.

TL;DR: It is suggested that male adults with ADHD show neural signs of abnormal reward processing and future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment.