G
Georg Krupitza
Researcher at Medical University of Vienna
Publications - 109
Citations - 4601
Georg Krupitza is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Cell cycle & Apoptosis. The author has an hindex of 29, co-authored 106 publications receiving 3961 citations.
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Journal ArticleDOI
In vitro cell migration and invasion assays.
Nina Kramer,Angelika Walzl,Christine Unger,Margit Rosner,Georg Krupitza,Markus Hengstschläger,Helmut Dolznig +6 more
TL;DR: A concise summary of established migration/invasion assays described in the literature is provided, list advantages, limitations and drawbacks, give a tabular overview for convenience and depict the basic principles of the assays graphically.
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Initial steps of metastasis: Cell invasion and endothelial transmigration
TL;DR: Future concepts of metastasis intervention must simultaneously address the collective, mesenchymal and amoeboid mechanisms of cell invasion in order to advance in anti-metastatic strategies as these different types of movement can coexist and cooperate.
Journal ArticleDOI
Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.
Angelika Riedl,Michaela Schlederer,Karoline Pudelko,Mira Stadler,Stefanie Walter,Daniela Unterleuthner,Christine Unger,Nina Kramer,Markus Hengstschläger,Lukas Kenner,Lukas Kenner,Dagmar Pfeiffer,Georg Krupitza,Helmut Dolznig +13 more
TL;DR: Colon cancer spheroids have decreased AKT–mTOR–S6K activity, spatial differences in signaling intensity as well as differing responses upon inhibition of the AKT-mTOR-S6k or mitogen-activated protein kinase (MAPK) axes in comparison with 2D cultures.
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Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse
Dontscho Kerjaschki,Zsuzsanna Bago-Horvath,Margaretha Rudas,Veronika Sexl,Veronika Sexl,Christine Schneckenleithner,Susanne Wolbank,Gregor Bartel,Sigurd Krieger,Romana Kalt,Brigitte Hantusch,Thomas Keller,Katalin Nagy-Bojarszky,Nicole Huttary,Ingrid Raab,Karin Lackner,Katharina Krautgasser,Helga Schachner,Klaus Kaserer,Sandra Rezar,Sybille Madlener,Caroline Vonach,Agnes Davidovits,Hitonari Nosaka,Hitonari Nosaka,Monika Hämmerle,Katharina Viola,Helmut Dolznig,Martin Schreiber,Alexander Nader,Wolfgang Mikulits,Michael Gnant,Satoshi Hirakawa,Michael Detmar,Kari Alitalo,Sebastian M.B. Nijman,Felix Offner,Thorsten J. Maier,Dieter Steinhilber,Georg Krupitza +39 more
TL;DR: In this article, the authors show that the formation of lymph node metastases in mammary carcinoma cells can be traced to the 12S-HETE following 15-lipoxygenase-1 (ALOX15) catalysis.
Journal ArticleDOI
Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells.
Sibylle Madlener,Christoph Illmer,Zsuzsanna Horvath,Philipp Saiko,Annemarie Losert,Irene Herbacek,Michael Grusch,Howard L. Elford,Georg Krupitza,Astrid Bernhaus,Monika Fritzer-Szekeres,Thomas Szekeres +11 more
TL;DR: Novel biochemical effects of GA are identified which could be the basis for further preclinical and in vivo studies and indicate ribonucleotide reductase inhibition in human HL-60 promyelocytic leukemia cells.