G
George Elia
Researcher at Queen Mary University of London
Publications - 47
Citations - 4284
George Elia is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Stem cell & Angiogenesis. The author has an hindex of 29, co-authored 47 publications receiving 4013 citations. Previous affiliations of George Elia include London Research Institute & Lincoln's Inn.
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Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion.
TL;DR: In this article, a targeted expression of a switchable form of the c-Myc protein to the skin epidermis, a well characterized homeostatic tissue, was shown to rapidly trigger proliferation and disrupts differentiation of postmitotic keratinocytes.
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Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells
TL;DR: This cell lineage is very commonly associated with gastrointestinal mucosal ulceration, and it is concluded that a principal in vivo role for EGF/URO is to stimulate ulcer healing throughout the gut through induction of this cell lineage in the adjacent mucosa.
Journal Article
Bottom-up Histogenesis of Colorectal Adenomas Origin in the Monocryptal Adenoma and Initial Expansion by Crypt Fission
Sean L. Preston,Wai Man Wong,Annie On-On Chan,Richard Poulsom,Rosemary Jeffery,Robert A. Goodlad,Nikki Mandir,George Elia,Marco Novelli,Walter F. Bodmer,Ian Tomlinson,Nicholas A. Wright +11 more
TL;DR: Examination of flat mucosa of three patients who had undergone colectomies for familial adenomatous polyposis and specimens from a XO/XY individual with FAP, the latter using in situ hybridization for the Y chromosome showed no instances of XY or XO adenOMatous epithelium growing down into crypts of the other genotype.
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Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.
Stuart McDonald,Stuart McDonald,Laura C. Greaves,Lydia Gutierrez–Gonzalez,Manuel Rodriguez–Justo,Maesha Deheragoda,Maesha Deheragoda,Simon J. Leedham,Robert W. Taylor,Chung Yin Lee,Sean L. Preston,Matthew A. Lovell,Toby Hunt,George Elia,Dahmane Oukrif,Rebecca Harrison,Marco Novelli,I Mitchell,David L. Stoker,Douglass M. Turnbull,Janusz Jankowski,Janusz Jankowski,Janusz Jankowski,Nicholas A. Wright,Nicholas A. Wright +24 more
TL;DR: The data show that human gastric body units are clonal, contain multiple multipotential stem cells, and provide definitive evidence for how mutations spread within the human stomach, and show how field cancerization develops.
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Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa.
T Wong,Luke Gammon,Lu Liu,Jemima E. Mellerio,Patricia J.C. Dopping-Hepenstal,John Pacy,George Elia,Rosemary Jeffery,Irene M. Leigh,Harshad Navsaria,John A. McGrath +10 more
TL;DR: This is the first study demonstrating that intradermal injections of allogeneic fibroblasts have therapeutic potential in human subjects with RDEB, and it is believed that this mutant protein may be partially functional and capable of increasing adhesion at the DEJ.