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Sean L. Preston
Researcher at Queen Mary University of London
Publications - 36
Citations - 2703
Sean L. Preston is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 20, co-authored 35 publications receiving 2513 citations. Previous affiliations of Sean L. Preston include London Research Institute & Barts Health NHS Trust.
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Journal ArticleDOI
Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process
Cathy Bennett,Nimish Vakil,Jacques J. Bergman,Rebecca Harrison,Robert D. Odze,Michael Vieth,Scott Sanders,Oliver Pech,Gaius Longcroft-Wheaton,Yvonne Romero,John M. Inadomi,Jan Tack,Douglas A. Corley,Hendrik Manner,Susi Green,David Al Dulaimi,Haythem Ali,Bill Allum,Mark R Anderson,Howard Curtis,Gary W. Falk,M. Brian Fennerty,Grant Fullarton,Kausilia K. Krishnadath,Stephen J. Meltzer,David Armstrong,Robert A. Ganz,Gianpaolo Cengia,James J. Going,John R. Goldblum,Charles Gordon,Heike I. Grabsch,Chris Haigh,Michio Hongo,David Johnston,Ricky Forbes-Young,Elaine Kay,Philip Kaye,Toni Lerut,Laurence Lovat,Lars Lundell,Philip Mairs,Tadakuza Shimoda,Stuart J. Spechler,Stephen J. Sontag,Peter Malfertheiner,Iain A. Murray,Manoj Nanji,David N. Poller,Krish Ragunath,Jaroslaw Regula,Renzo Cestari,Neil A. Shepherd,Rajvinder Singh,Hubert J. Stein,Nicholas J. Talley,Jean Paul Galmiche,Tony C.K. Tham,Peter Watson,Lisa Yerian,Massimo Rugge,Thomas W. Rice,John Hart,Stuart Gittens,David Hewin,Juergen Hochberger,Peter J. Kahrilas,Sean L. Preston,Richard E. Sampliner,Prateek Sharma,Robert C. Stuart,Kenneth K. Wang,Irving Waxman,Chris Abley,Duncan Loft,Ian D. Penman,Nicholas J. Shaheen,Amitabh Chak,Gareth Davies,L. J. Dunn,Yngve Falck-Ytter,John deCaestecker,Pradeep Bhandari,Christian Ell,S. Michael Griffin,Stephen Attwood,Hugh Barr,John J.B. Allen,Mark K. Ferguson,Paul Moayyedi,Janusz Jankowski,Janusz Jankowski,Janusz Jankowski +92 more
TL;DR: An international, multidisciplinary, systematic, evidence-based review of different management strategies for patients with Barrett's esophagus and dysplasia or early-stage EA and developed a data-sifting platform and used the Delphi process to create evidence- based consensus statements.
Journal ArticleDOI
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
Laura C. Greaves,Sean L. Preston,Paul J. Tadrous,Robert W. Taylor,Martin J. Barron,Dahmane Oukrif,Simon J. Leedham,Maesha Deheragoda,Peter Sasieni,Marco Novelli,Janusz Jankowski,Douglass M. Turnbull,Nicholas A. Wright,Stuart McDonald +13 more
TL;DR: It is demonstrated definitively that crypt fission is the mechanism by which mutations spread in the normal human colon, which has important implications for the biology of the normal adult human colon and possibly for the growth and spread of colorectal neoplasms.
Journal Article
Bottom-up Histogenesis of Colorectal Adenomas Origin in the Monocryptal Adenoma and Initial Expansion by Crypt Fission
Sean L. Preston,Wai Man Wong,Annie On-On Chan,Richard Poulsom,Rosemary Jeffery,Robert A. Goodlad,Nikki Mandir,George Elia,Marco Novelli,Walter F. Bodmer,Ian Tomlinson,Nicholas A. Wright +11 more
TL;DR: Examination of flat mucosa of three patients who had undergone colectomies for familial adenomatous polyposis and specimens from a XO/XY individual with FAP, the latter using in situ hybridization for the Y chromosome showed no instances of XY or XO adenOMatous epithelium growing down into crypts of the other genotype.
Journal ArticleDOI
Multiple Organ Engraftment by Bone‐Marrow‐Derived Myofibroblasts and Fibroblasts in Bone‐Marrow‐Transplanted Mice
Natalie C. Direkze,Stuart J. Forbes,Mairi Brittan,Toby Hunt,Rosemary Jeffery,Sean L. Preston,Richard Poulsom,Kairbaan Hodivala-Dilke,Malcolm R. Alison,Nicholas A. Wright +9 more
TL;DR: It is suggested that the bone marrow contributes to a circulating population of cells and, in the context of injury, these cells are recruited and contribute to tissue repair.
Journal ArticleDOI
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.
Stuart McDonald,Stuart McDonald,Laura C. Greaves,Lydia Gutierrez–Gonzalez,Manuel Rodriguez–Justo,Maesha Deheragoda,Maesha Deheragoda,Simon J. Leedham,Robert W. Taylor,Chung Yin Lee,Sean L. Preston,Matthew A. Lovell,Toby Hunt,George Elia,Dahmane Oukrif,Rebecca Harrison,Marco Novelli,I Mitchell,David L. Stoker,Douglass M. Turnbull,Janusz Jankowski,Janusz Jankowski,Janusz Jankowski,Nicholas A. Wright,Nicholas A. Wright +24 more
TL;DR: The data show that human gastric body units are clonal, contain multiple multipotential stem cells, and provide definitive evidence for how mutations spread within the human stomach, and show how field cancerization develops.