G
George Sigal
Researcher at Harvard University
Publications - 95
Citations - 6383
George Sigal is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 24, co-authored 81 publications receiving 5900 citations. Previous affiliations of George Sigal include Wilmington University.
Papers
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Patent
Multi-array, multi-specific electrochemiluminescence testing
Jacob N. Wohlstadter,James L. Wilbur,George Sigal,Mark Martin,Liang-Hong Guo,Alan B. Fischer,Jon Leland +6 more
TL;DR: In this article, a patterned multi-array, multi-specific surfaces for use in diagnostics are presented for detecting or measuring an analyte of interest using electrochemiluminescence methods.
Journal ArticleDOI
Effect of Surface Wettability on the Adsorption of Proteins and Detergents
TL;DR: In this article, surface plasmon spectroscopy was used to study the effect of surface wettability on the nonspecific adsorption of proteins and detergents to self-assembled monolayers (SAMs) of alkanethiolates on gold.
Journal ArticleDOI
A self-assembled monolayer for the binding and study of histidine-tagged proteins by surface plasmon resonance.
TL;DR: Surface plasmon resonance studies showed that His-tagged proteins adsorbed on the NTA-SAM retained a greater ability to participate in binding interactions with proteins in solution than protein immobilized in a thin dextran gel layer by covalent coupling.
Patent
Assay plates, reader systems and methods for luminescence test measurements
Jacob N. Wohlstadter,Eli N. Glezer,James L. Wilbur,George Sigal,Kent Johnson,Charles Clinton,Alan Kishbaugh,Bandele Jeffrey-Coker,Jeff D. Debad,Alan B. Fischer +9 more
TL;DR: In this article, an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence in the wells or assay regions of the assay modules and measure the induced luminecence.
Journal ArticleDOI
Surface Plasmon Resonance Permits in Situ Measurement of Protein Adsorption on Self-Assembled Monolayers of Alkanethiolates on Gold
TL;DR: In this paper, surface plasmon resonance (SPR) spectroscopy was used to measure the nonspecific adsorption of proteins to self-assembled monolayers (SAMs) of alkanethiolates on gold in situ and in real time.