U
Urban Deutsch
Researcher at University of Bern
Publications - 95
Citations - 16831
Urban Deutsch is an academic researcher from University of Bern. The author has contributed to research in topics: Blood–brain barrier & Endothelial stem cell. The author has an hindex of 48, co-authored 94 publications receiving 15811 citations. Previous affiliations of Urban Deutsch include University of Tübingen & University of Münster.
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Journal ArticleDOI
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
Thomas N. Sato,Yuzuru Tozawa,Urban Deutsch,Karen Wolburg-Buchholz,Yuko Fujiwara,Maureen Gendron-Maguire,Thomas Gridley,Hartwig Wolburg,Werner Risau,Ying Qin +9 more
TL;DR: In vivo analyses of embryos deficient in Tie-2 showed that it is important in angiogen-esis, particularly for vascular network formation in endothelial cells, which contrasts with previous reports on Tie-1 function in vasculogenesis and/or endothelial cell survival.
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Structural and functional diversity of connexin genes in the mouse and human genome
Klaus Willecke,Jürgen Eiberger,Joachim Degen,Dominik Eckardt,Alessandro Romualdi,Martin Güldenagel,Urban Deutsch,Goran Söhl +7 more
TL;DR: This review compares currently identified connexin genes in both the mouse and human genome and discusses the functions of gap junctions deduced from targeted mouse mutants and human genetic disorders.
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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Yingdi Wang,Masanori Nakayama,Mara E. Pitulescu,Tim S. Schmidt,Magdalena L. Bochenek,Magdalena L. Bochenek,Akira Sakakibara,Susanne Adams,Susanne Adams,Alice Davy,Urban Deutsch,Urs Lüthi,Alcide Barberis,Laura E. Benjamin,Taija Makinen,Catherine D. Nobes,Ralf H. Adams,Ralf H. Adams +17 more
TL;DR: It is shown with genetic experiments in mouse and zebrafish that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behaviour and motility in the angiogenic endothelium, and shows that full VEGFR3 signalling is coupled to receptor internalization.
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Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
Ralf H. Adams,George A. Wilkinson,Cornelia Weiss,Francesca Diella,Nicholas W. Gale,Urban Deutsch,Werner Risau,Rüdiger Klein +7 more
TL;DR: EphrinB ligands induce capillary sprouting in vitro with a similar efficiency as angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF), demonstrating a stimulatory role of ephrins in the remodeling of the developing vascular system.
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Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.
TL;DR: The isolation and characterization of Pax‐3 is described, a novel murine paired box gene expressed exclusively during embryogenesis that specifically recognizes the e5 sequence present upstream of the Drosophila even‐skipped gene.