G
Georges Rawadi
Researcher at Pasteur Institute
Publications - 43
Citations - 8229
Georges Rawadi is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Wnt signaling pathway & LRP5. The author has an hindex of 27, co-authored 41 publications receiving 7890 citations. Previous affiliations of Georges Rawadi include Protein Sciences.
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Journal ArticleDOI
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Yaoqin Gong,R. B. Slee,Naomi Fukai,Georges Rawadi,Sergio Roman-Roman,Anthony M. Reginato,H. W. Wang,Tim Cundy,Francis H. Glorieux,Dorit Lev,M. Zacharin,Konrad Oexle,Jose Marcelino,Wafaa M. Suwairi,Shauna Heeger,G. Sabatakos,Suneel S. Apte,W. N. Adkins,J. Allgrove,M. Arslan-Kirchner,J. A. Batch,Peter Beighton,Graeme C.M. Black,R. G. Boles,L. M. Boon,C. Borrone,Han G. Brunner,G. F. Carle,Bruno Dallapiccola,A. De Paepe,B. Floege,M. L. Halfhide,Barbara Hall,Raoul C.M. Hennekam,Tatsuo Hirose,A. Jans,Harald Jüppner,Chong Ae Kim,K. Keppler-Noreuil,A. Kohlschuetter,Didier Lacombe,M. Lambert,E. Lemyre,T. Letteboer,Leena Peltonen,Rajkumar Ramesar,M. Romanengo,H. Somer,E. Steichen-Gersdorf,Beat Steinmann,Beth A. Sullivan,Andrea Superti-Furga,W. Swoboda,M. J. van den Boogaard,W. Van Hul,Miikka Vikkula,Marcela Votruba,Bernhard Zabel,Teresa Garcia,Roland Baron,Bjorn R. Olsen,Matthew L. Warman +61 more
TL;DR: It is reported that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth and is important for the establishment of peak bone mass.
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Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
Egil Lien,Egil Lien,Timothy J. Sellati,Atsutoshi Yoshimura,Trude Helen Flo,Georges Rawadi,Robert W. Finberg,J. David Carroll,Terje Espevik,Robin R. Ingalls,Justin D. Radolf,Douglas T. Golenbock +11 more
TL;DR: It is concluded that diverse pathogens activate cells through TLR2 and proposed that this molecule is a central pattern recognition receptor in host immune responses to microbial invasion.
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BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
TL;DR: It is shown that a Wnt autocrine loop mediates the induction of alkaline phosphatase and mineralization by BMP‐2 in pre‐osteoblastic cells.
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Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton
Roland Baron,Georges Rawadi +1 more
TL;DR: The recent identification of a link between bone mass in humans and gain- or loss-of-function mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein 5 or sclerostin has called the attention of academic and industry scientists and clinicians to the importance of this signaling pathway in skeletal biology and disease.
Journal ArticleDOI
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.
Frederic Morvan,Kim E. Boulukos,Philippe Clément-Lacroix,Sergio Roman Roman,Isabelle Suc-Royer,Béatrice Vayssière,Patrick Ammann,Patrick Martin,Sonia Pinho,Philippe Pognonec,Patrick Mollat,Christof Niehrs,Roland Baron,Georges Rawadi +13 more
TL;DR: It is shown that Dkk1, unlike Dkk2, negatively regulates osteoblast differentiation and bone formation, and Wnt/β‐catenin signaling has been proven to play a central role in bone biology.