L
Leena Peltonen
Researcher at Wellcome Trust Sanger Institute
Publications - 195
Citations - 35376
Leena Peltonen is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 87, co-authored 195 publications receiving 33605 citations. Previous affiliations of Leena Peltonen include National Institutes of Health & University of California, Los Angeles.
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Journal ArticleDOI
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Yaoqin Gong,R. B. Slee,Naomi Fukai,Georges Rawadi,Sergio Roman-Roman,Anthony M. Reginato,H. W. Wang,Tim Cundy,Francis H. Glorieux,Dorit Lev,M. Zacharin,Konrad Oexle,Jose Marcelino,Wafaa M. Suwairi,Shauna Heeger,G. Sabatakos,Suneel S. Apte,W. N. Adkins,J. Allgrove,M. Arslan-Kirchner,J. A. Batch,Peter Beighton,Graeme C.M. Black,R. G. Boles,L. M. Boon,C. Borrone,Han G. Brunner,G. F. Carle,Bruno Dallapiccola,A. De Paepe,B. Floege,M. L. Halfhide,Barbara Hall,Raoul C.M. Hennekam,Tatsuo Hirose,A. Jans,Harald Jüppner,Chong Ae Kim,K. Keppler-Noreuil,A. Kohlschuetter,Didier Lacombe,M. Lambert,E. Lemyre,T. Letteboer,Leena Peltonen,Rajkumar Ramesar,M. Romanengo,H. Somer,E. Steichen-Gersdorf,Beat Steinmann,Beth A. Sullivan,Andrea Superti-Furga,W. Swoboda,M. J. van den Boogaard,W. Van Hul,Miikka Vikkula,Marcela Votruba,Bernhard Zabel,Teresa Garcia,Roland Baron,Bjorn R. Olsen,Matthew L. Warman +61 more
TL;DR: It is reported that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth and is important for the establishment of peak bone mass.
Journal ArticleDOI
Common variants conferring risk of schizophrenia
Hreinn Stefansson,Hreinn Stefansson,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Stacy Steinberg,Stacy Steinberg,Ole A. Andreassen,Sven Cichon,Dan Rujescu,Thomas Werge,Olli Pietilainen,Ole Mors,Preben Bo Mortensen,Engilbert Sigurdsson,Omar Gustafsson,Mette Nyegaard,Annamari Tuulio-Henriksson,Andres Ingason,Thomas Hansen,Jaana Suvisaari,Jouko Lönnqvist,Tiina Paunio,Anders D. Børglum,Anders D. Børglum,Annette M. Hartmann,Anders Fink-Jensen,Merete Nordentoft,David M. Hougaard,Bent Nørgaard-Pedersen,Yvonne Böttcher,Jes Olesen,René Breuer,Hans-Jürgen Möller,Ina Giegling,Henrik B. Rasmussen,Sally Timm,Manuel Mattheisen,István Bitter,János Réthelyi,Brynja B. Magnusdottir,Thordur Sigmundsson,Pall I. Olason,Gisli Masson,Jeffrey R. Gulcher,Magnús Haraldsson,Ragnheidur Fossdal,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Mirella Ruggeri,Sarah Tosato,Barbara Franke,Eric Strengman,Lambertus A. Kiemeney,Ingrid Melle,Srdjan Djurovic,Lilia I. Abramova,Kaleda Vg,Julio Sanjuán,Rosa de Frutos,Elvira Bramon,Evangelos Vassos,Gillian Fraser,Ulrich Ettinger,Marco Picchioni,Nicholas Walker,T. Toulopoulou,Anna C. Need,Dongliang Ge,Joeng Lim Yoon,Kevin V. Shianna,Nelson B. Freimer,Rita M. Cantor,Robin M. Murray,Augustine Kong,Vera Golimbet,Angel Carracedo,Celso Arango,Javier Costas,Erik G. Jönsson,Lars Terenius,Ingrid Agartz,Hannes Petursson,Markus M. Nöthen,Marcella Rietschel,Paul M. Matthews,Pierandrea Muglia,Leena Peltonen,David St Clair,David Goldstein,Kari Stefansson,Kari Stefansson,David A. Collier,David A. Collier +94 more
TL;DR: Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
Journal ArticleDOI
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Cathryn M. Lewis,Douglas F. Levinson,Lesley H. Wise,Lynn E. DeLisi,Richard E. Straub,Iiris Hovatta,Nigel Williams,Sibylle G. Schwab,Ann E. Pulver,Stephen V. Faraone,Linda M. Brzustowicz,Linda M. Brzustowicz,Charles A. Kaufmann,David L. Garver,Hugh Gurling,Eva Lindholm,Hilary Coon,Hans W. Moises,William Byerley,Sarah H. Shaw,Andrea Mesén,Robin Sherrington,F. Anthony O'Neill,Dermot Walsh,Kenneth S. Kendler,Jesper Ekelund,Tiina Paunio,Jouko Lönnqvist,Leena Peltonen,Leena Peltonen,Michael Conlon O'Donovan,Michael John Owen,Dieter B. Wildenauer,Wolfgang Maier,Gerald Nestadt,Jean-Louis Blouin,Stylianos E. Antonarakis,Bryan J. Mowry,Jeremy M. Silverman,Raymond R. Crowe,C. Robert Cloninger,Ming T. Tsuang,Dolores Malaspina,Jill M. Harkavy-Friedman,Dragan M. Svrakic,Anne S. Bassett,Jennifer A. Holcomb,Gursharan Kalsi,Andrew McQuillin,Jon Brynjolfson,Thordur Sigmundsson,Hannes Petursson,Elena Jazin,Tómas Zoega,Tómas Helgason +54 more
TL;DR: The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
Journal ArticleDOI
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
Johanna Aaltonen,Petra Björses,Jaakko Perheentupa,Nina Horelli–Kuitunen,Aarno Palotie,Leena Peltonen,Yeon Su Lee,Fiona Francis,Steffen Henning,Cora S. Thiel,Hans Leharach,Marie-Laure Yaspo +11 more
TL;DR: A novel gene, AIRE, encoding for a putative nuclear protein featuring two PHD-type zinc-finger motifs is isolated, suggesting its involvement in transcriptional regulation in APECED, suggesting the molecular basis of autoimmunity.
Journal ArticleDOI
Classical twin studies and beyond.
TL;DR: An overview of the current resources for twin research is provided to obtain insights into the genetic epidemiology of complex traits and diseases, to study the interaction of genotype with sex, age and lifestyle factors, and the causes of co-morbidity between traits and disease.