G
Georgia Sotiropoulou
Researcher at RMIT University
Publications - 105
Citations - 4907
Georgia Sotiropoulou is an academic researcher from RMIT University. The author has contributed to research in topics: Kallikrein & Cancer. The author has an hindex of 38, co-authored 97 publications receiving 4589 citations. Previous affiliations of Georgia Sotiropoulou include Mount Sinai Hospital, Toronto & University of Patras.
Papers
More filters
Journal ArticleDOI
Redirecting drug repositioning to discover innovative cosmeceuticals
TL;DR: In this paper, the authors propose target repositioning, a new term to highlight that druggable protein targets implicated in multiple diseases (hubs in the diseasome) can be exploited to accelerate the discovery of molecularly targeted cosmeceuticals that can promote skin health.
Journal ArticleDOI
Development of an immunofluorometric assay for human kallikrein 15 (KLK15) and identification of KLK15 in tissues and biological fluids.
Julie L.V. Shaw,Linda Grass,Georgia Sotiropoulou,Eleftherios P. Diamandis,Eleftherios P. Diamandis +4 more
TL;DR: Analytical technology for human kallikrein 15, including recombinant protein, specific antibodies, and a sensitive and specific ELISA immunoassay are developed, which will allow for analysis of KLK15 protein expression levels in tissues and biological fluids, both normal and cancerous.
Journal ArticleDOI
KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes.
Konstantinos Gus Sidiropoulos,Konstantinos Gus Sidiropoulos,Qiang Ding,Georgios Pampalakis,Nicole M.A. White,Nicole M.A. White,Peter Boulos,Georgia Sotiropoulou,George M. Yousef,George M. Yousef +9 more
TL;DR: It was demonstrated that KLK6 overexpression and likely its proteolytic activity is associated with alterations in downstream miRNAs and their targets, and these differ with the molecular subtypes of breast cancer, which partly explains the different characteristics of Breast cancer subtypes.
Journal ArticleDOI
Novel splice variants of prostate-specific antigen and applications in diagnosis of prostate cancer☆
TL;DR: A novel splice variant of PSA was identified, PSA-SV5, that may be exploited in clinical diagnosis to distinguish prostate cancer from benign prostate hyperplasia and showed that it is specifically expressed in prostate cancers.
Journal ArticleDOI
KLK6 protease accelerates skin tumor formation and progression.
Nikolas Khoury,Eleni Zingkou,Georgios Pampalakis,Michail Sofopoulos,Vassilis Zoumpourlis,Georgia Sotiropoulou +5 more
TL;DR: Kallikrein-related peptidase 6 is identified as a new tumor-promoting factor of early skin cancer and suggested that KLK6 is an important molecular link in the development of skin inflammation and in tumor- Promoting inflammatory processes.