G
Gerald T. Ankley
Researcher at United States Environmental Protection Agency
Publications - 374
Citations - 27860
Gerald T. Ankley is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Vitellogenin & Pimephales promelas. The author has an hindex of 82, co-authored 356 publications receiving 25514 citations. Previous affiliations of Gerald T. Ankley include Michigan State University & Pacific Northwest National Laboratory.
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Journal ArticleDOI
Natural Variation in Fish Transcriptomes: Comparative Analysis of the Fathead Minnow (Pimephales promelas) and Zebrafish (Danio rerio).
Rong-Lin Wang,David C. Bencic,Natàlia Garcia-Reyero,Edward J. Perkins,Daniel L. Villeneuve,Gerald T. Ankley,Adam D. Biales +6 more
TL;DR: There was significant conservation of both the genomes and transcriptomes between fathead minnow and zebrafish, and the overall level of within-batch variation was quite low in fish ovary tissue, making it a suitable system for studying chemical stressors with subtle biological effects.
Journal ArticleDOI
Sex-specific gonadal and gene expression changes throughout development in fathead minnow.
Jessica K. Leet,Kelsey E. Lesteberg,Heiko L. Schoenfuss,Allen W. Olmstead,Jon J. Amberg,Gerald T. Ankley,Maria S. Sepúlveda +6 more
TL;DR: Evaluation of molecular markers in combination with gender identification help to better understand the mechanisms regulating sex differentiation in fathead minnows and how endocrine-disrupting chemicals may alter these processes.
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Mechanism-based categorization of aromatase inhibitors: a potential discovery and screening tool
TL;DR: A mechanism-based structure–activity relationship (SAR) categorization framework highlighting the most important chemical structural features responsible for inhibition of aromatase activity was developed, and a software tool was developed that allowed a decision tree (profile) to be built discriminating AIs by mechanism and potency.
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A method for the determination of genetic sex in the fathead minnow, Pimephales promelas, to support testing of endocrine-active chemicals.
Allen W. Olmstead,Daniel L. Villeneuve,Gerald T. Ankley,Jenna E. Cavallin,Annelie Lindberg-Livingston,Leah C. Wehmas,Sigmund J. Degitz +6 more
TL;DR: A method for determining the genetic sex in the commonly used ecotoxicological model, the fathead minnow (Pimephales promelas), and can be incorporated into endocrine toxicity assays that examine the effects of chemicals on gonad differentiation.
Journal ArticleDOI
II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish.
Daniel L. Villeneuve,Natàlia Garcia-Reyero,Natàlia Garcia-Reyero,Dalma Martinović,Nathaniel D. Mueller,Jenna E. Cavallin,Elizabeth J. Durhan,Elizabeth A. Makynen,Kathleen M. Jensen,Michael D. Kahl,Lindsey S. Blake,Edward J. Perkins,Gerald T. Ankley +12 more
TL;DR: Results suggest that non-lethal concentrations of haloperidol do not induce ovarian molecular responses that could serve as biomarkers of exposure to D2R antagonists, but may impact behavior.