Gerald T. Ankley

TL;DR: Information is presented on the classes of environmental chemicals that display antiandrogenic and androgenic activities in vitro and in vivo and an insight into how exposure to mixtures these chemicals might behave in utero is provided.

TL;DR: Existing methods suitable for identifying chemicals with these mechanisms of action in reptiles and amphibians are limited, but in the future, tests with species from these classes may prove highly effective as screens.

TL;DR: Results of this study indicate that the proposed fathead minnow assay should effectively identify test chemicals as potential aromatase inhibitors, both in the context of their reproductive toxicity and the specific mechanism of action.

TL;DR: Water collected downstream of the Kraft mill on the Fenholloway River contains unidentified androgenic substances whose presence is associated with masculinization of female mosquitofish.

TL;DR: Attributes of the fathead minnow make it an excellent model for addressing new challenges in aquatic toxicology, including identification of sensitive life-stages/endpoints for chemicals with differing modes/mechanisms of action, predicting population-level effects based on data collected from lower levels of biological organization, and exploring the emerging role of genomics in research and regulation.