Open Access
Supplementary Materials for Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
Wolfgang Hueber,Dhavalkumar D. Patel,Thaddeus P. Dryja,Andrew M Wright,Gerard Bruin,Christian Antoni,Michael H. Gold,Patrick Durez,Paul P. Tak,Juan J. Go,C. Stephen Foster,Rosa Y. Kim,C. Michael Samson,Naomi S. Falk,David S. Chu,David Callanan,Asifa Haider +16 more
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The article was published on 2010-01-01 and is currently open access. It has received 742 citations till now. The article focuses on the topics: Interleukin 17 & Psoriasis.read more
Citations
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10 Years of GWAS Discovery: Biology, Function, and Translation
Peter M. Visscher,Naomi R. Wray,Qian Zhang,Pamela Sklar,Mark I. McCarthy,Matthew A. Brown,Jian Yang +6 more
TL;DR: The remarkable range of discoveriesGWASs has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics are reviewed.
Journal ArticleDOI
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
Wolfgang Hueber,Bruce E. Sands,Steve Lewitzky,Marc Vandemeulebroecke,Walter Reinisch,Peter D.R. Higgins,Jan Wehkamp,Brian G. Feagan,Michael D Yao,Marek Karczewski,Jacek Karczewski,Nicole Pezous,Stephan Bek,Gerard Bruin,Bjoern Mellgard,Claudia Berger,Marco Londei,Arthur P. Bertolino,Gervais Tougas,Simon Travis +19 more
TL;DR: Blockade of IL-17A was ineffective and higher rates of adverse events were noted compared with placebo, and unfavourable responses on secukinumab were driven by patients with elevated inflammatory markers.
Journal ArticleDOI
Functional Specialization of Interleukin-17 Family Members
TL;DR: The identified functions of each IL-17 family member are described and the potential of these molecules as therapeutic targets are discussed.
Journal ArticleDOI
Targeting IL-17 and TH17 cells in chronic inflammation.
Pierre Miossec,Jay K. Kolls +1 more
TL;DR: This Review focuses on the current knowledge of the IL-17–TH17 cell pathway to better understand the positive as well as potential negative consequences of targeting them.
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Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis
Kim A. Papp,Craig L. Leonardi,Alan Menter,Jean-Paul Ortonne,James G. Krueger,Gregory Kricorian,Girish A. Aras,Juan Li,Chris B. Russell,Elizabeth H.Z. Thompson,Scott Baumgartner +10 more
TL;DR: Bdalumab significantly improved plaque psoriasis in this 12-week, phase 2 study and was superior to placebo in all comparisons.
References
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Modified disease activity scores that include twenty-eight-joint counts : development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
M.L.L. Prevoo,M.A. van 't Hof,H.H. Kuper,M.A. van Leeuwen,L. B. A. Van De Putte,P.L.C.M. van Riel +5 more
TL;DR: The Modified DAS that included 28-joint counts were able to discriminate between high and low disease activity (as indicated by clinical decisions of rheumatologists) and are as valid as disease activity scores that include more comprehensive joint counts.
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IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
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Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.
Jonathan C. W. Edwards,Leszek Szczepanski,Jacek Szechiński,Anna Filipowicz-Sosnowska,Paul Emery,D. Close,Randall M Stevens,T. Shaw +7 more
TL;DR: In patients with active rheumatoid arthritis despite methotrexate treatment, a single course of two infusions of rituximab, alone or in combination with either cyclophosphamide or continued methotRexate, provided significant improvement in disease symptoms at both weeks 24 and 48.
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New visual acuity charts for clinical research
TL;DR: Three new visual acuity charts facilitate quantitative use ofVisual acuity test results by providing high-contrast lettering on washable white polystyrene on which to test right and left eyes.
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IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
TL;DR: The factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.
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Secukinumab in plaque psoriasis--results of two phase 3 trials.
Richard G. Langley,Boni E. Elewski,Mark Lebwohl,Kristian Reich,Christopher E.M. Griffiths,Kim A. Papp,Lluís Puig,Hidemi Nakagawa,Lynda Spelman,Bárður Sigurgeirsson,Enrique Rivas,Tsen-Fang Tsai,Norman Wasel,Stephen K. Tyring,Thomas Salko,Isabelle Hampele,Marianne Notter,Alexander Karpov,Silvia Helou,Charis Papavassilis +19 more