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Irina Koroleva
Researcher at Novartis
Publications - 28
Citations - 1399
Irina Koroleva is an academic researcher from Novartis. The author has contributed to research in topics: Secukinumab & Southern blot. The author has an hindex of 7, co-authored 24 publications receiving 1258 citations. Previous affiliations of Irina Koroleva include Russian Academy of Sciences & University of Iowa.
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Journal ArticleDOI
Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
Wolfgang Hueber,Dhavalkumar D. Patel,Thaddeus P. Dryja,Andrew M Wright,Irina Koroleva,Gerard Bruin,Christian Antoni,Zoe Diana Draelos,Michael H. Gold,Patrick Durez,Paul P. Tak,Juan J. Gomez-Reino,C. Stephen Foster,Rosa Y. Kim,C. Michael Samson,Naomi S. Falk,David S. Chu,David Callanan,Quan Dong Nguyen,Kristine Rose,Asifa Haider,Franco Di Padova +21 more
TL;DR: The results demonstrate that IL-17A participates in psoriasis, rheumatoid arthritis, and uveitis and that the antibody against this cytokine may be an effective therapeutic agent, and warrant larger clinical trials to assess further the safety and efficacy of AIN457.
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Transcriptional patterns in both host and bacterium underlie a daily rhythm of anatomical and metabolic change in a beneficial symbiosis
Andrew M. Wier,Andrew M. Wier,Spencer V. Nyholm,Mark J. Mandel,Mark J. Mandel,R. Prisca Massengo-Tiassé,Amy L. Schaefer,Amy L. Schaefer,Irina Koroleva,Irina Koroleva,Sandra Splinter-BonDurant,Bartley Brown,Liliana Manzella,Liliana Manzella,Einat Snir,Hakeem Almabrazi,Todd E. Scheetz,Maria de Fatima Bonaldo,Thomas L. Casavant,M. Bento Soares,John E. Cronan,Jennifer L. Reed,Edward G. Ruby,Margaret J. McFall-Ngai +23 more
TL;DR: The transcriptional, metabolic, and ultrastructural characteristics of a diel rhythm that occurs in the symbiosis between the squid Euprymna scolopes and the luminous bacterium Vibrio fischeri are described.
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Effects of colonization, luminescence, and autoinducer on host transcription during development of the squid-vibrio association
Carlene K. Chun,Joshua V. Troll,Irina Koroleva,Bartley Brown,Liliana Manzella,Einat Snir,Hakeem Almabrazi,Todd E. Scheetz,Maria de Fatima Bonaldo,Thomas L. Casavant,M. Bento Soares,Edward G. Ruby,Margaret J. McFall-Ngai +12 more
TL;DR: Putative host receptors for bacterial surface molecules known to induce squid development are up-regulated by symbiont light production, suggesting that bioluminescence plays a key role in preparing the host for bacteria-induced development.
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IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis.
James G. Krueger,Keith A. Wharton,Thomas Schlitt,Maria Suprun,Rebecca I. Torene,Xiaoyu Jiang,Claire Q.F. Wang,Judilyn Fuentes-Duculan,Nicole Hartmann,Thomas Peters,Irina Koroleva,Rainer Hillenbrand,Martin Letzkus,Xiaojing Yu,Yue Li,Anton Glueck,Anke Hasselberg,Brian Flannery,Mayte Suárez-Fariñas,Wolfgang Hueber +19 more
TL;DR: The data suggest that IL-17A is the critical node within multidimensional pathogenic immune circuits that maintain psoriasis plaques, and that early reduction of IL- 17A-dependent feed-forward transcripts synthesized by hyperplastic keratinocytes favors plaque resolution.
Journal ArticleDOI
First-in-human high-cumulative-dose stem cell therapy in idiopathic pulmonary fibrosis with rapid lung function decline.
Alexander Averyanov,Irina Koroleva,M. A. Konoplyannikov,V. A. Revkova,Victor Lesnyak,V. A. Kalsin,Olesya Danilevskaya,Alexey Nikitin,Anna Sotnikova,Svetlana L. Kotova,Svetlana L. Kotova,Vladimir P. Baklaushev +11 more
TL;DR: In patients with IPF and a rapid pulmonary function decline, therapy with high doses of allogeneic MSCs is a safe and promising method to reduce disease progression.