G
Gerard C. L. Wong
Researcher at University of California, Los Angeles
Publications - 183
Citations - 10694
Gerard C. L. Wong is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Antimicrobial peptides & Membrane. The author has an hindex of 51, co-authored 173 publications receiving 8831 citations. Previous affiliations of Gerard C. L. Wong include California Institute of Technology & University of California, Berkeley.
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Journal ArticleDOI
The Pel Polysaccharide Can Serve a Structural and Protective Role in the Biofilm Matrix of Pseudomonas aeruginosa
Kelly M. Colvin,Vernita Gordon,Keiji Murakami,Bradley R. Borlee,Daniel J. Wozniak,Gerard C. L. Wong,Matthew R. Parsek +6 more
TL;DR: It is shown that expression of the pel gene cluster and PelF protein levels are enhanced during biofilm growth compared to liquid cultures, suggesting that Pel is capable of playing both a structural and a protective role in P. aeruginosa biofilms.
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Arginine‐rich cell‐penetrating peptides
TL;DR: The evidence for the broad range of proposed mechanisms for cell‐penetrating peptides internalization is reviewed, and it is shown that each distinct process requires negative Gaussian membrane curvature as a necessary condition.
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Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes
TL;DR: A controlled formulation of aptamerconjugated, cisplatin-encapsulating multifunctional liposomes is reported, which shows for the first time that a complementary DNA (cDNA) and liposome-based system based on EPR still has undesirable systemic side effects and suboptimal antitumor efficacy.
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Living in the matrix: assembly and control of Vibrio cholerae biofilms
Jennifer K. Teschler,David Zamorano-Sánchez,Andrew S. Utada,Christopher J. A. Warner,Gerard C. L. Wong,Roger G. Linington,Fitnat H. Yildiz +6 more
TL;DR: This Review discusses V. cholerae surface attachment, various matrix components and the regulatory networks controlling biofilm formation in this model organism that spends much of its life cycle outside of the human host in the aquatic environment.
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Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms.
Kun Zhao,Boo Shan Tseng,Bernard Beckerman,Fan Jin,Maxsim Gibiansky,Joe J. Harrison,Erik Luijten,Matthew R. Parsek,Gerard C. L. Wong +8 more
TL;DR: This Pareto-type behaviour indicates that the bacterial community self-organizes in a manner analogous to a capitalist economic system, a ‘rich-get-richer’ mechanism of Psl accumulation that results in a small number of ‘elite’ cells becoming extremely enriched in communally produced Psl.