G
Gérard Gacon
Researcher at Paris Descartes University
Publications - 64
Citations - 2738
Gérard Gacon is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Phosphorylation & Tyrosine. The author has an hindex of 29, co-authored 64 publications receiving 2550 citations. Previous affiliations of Gérard Gacon include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.
Viviana Jullien-Flores,Olivier Dorseuil,Francisco Romero,Frank Letourneur,Sentob Saragosti,Roland Berger,Armand Tavitian,Gérard Gacon,Jacques Camonis +8 more
TL;DR: It is proposed that the Rho pathway is involved in membrane and cytoskeleton modifications after mitogenic stimulation and acts in parallel to and synergistically with the Ras pathway, and these pathways are linked through a cascade composed of Ras RalGDS Ral RLIP76 CDC42/Rac1/Rho.
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MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells
Aminata Touré,Olivier Dorseuil,Laurence Morin,Paula M. Timmons,Bernard Jégou,Louise Reibel,Gérard Gacon +6 more
TL;DR: Protein sequence similarity and analogous developmental and tissue specificities of gene expression support the hypothesis that RotundRACGAP and MgcRacGAP have equivalent functions in insect and mammalian germ cells.
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The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1.
Stéphanie Torrino,Orane Visvikis,Orane Visvikis,Anne Doye,Anne Doye,Laurent Boyer,Laurent Boyer,Caroline Stefani,Caroline Stefani,Patrick Munro,Patrick Munro,Jacques Bertoglio,Gérard Gacon,Amel Mettouchi,Emmanuel Lemichez,Emmanuel Lemichez +15 more
TL;DR: The essential role of the tumor suppressor HACE1, a HECT-domain containing E3 ubiquitin-ligase, in the targeting of Rac1 to UPS is reported, establishing the role in controlling Rac1 ubiquitylation and activity.
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Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network
Adèle Faucherre,Pierrette Desbois,Véronique Satre,Joël Lunardi,Olivier Dorseuil,Gérard Gacon +5 more
TL;DR: OCRL1 appears to be a bifunctional protein which, in addition to its PIP2 5-phosphatase activity, binds to Rac GTPase, and this novel property may play a role in localizing OCRL1 to the trans-Golgi network.
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Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides.
TL;DR: It is shown, for the first time in whole cells, that superoxide production is modulated by the Rac protein content, thus demonstrating the physiological role of Rac proteins in the regulation of NADPH-oxidase.