Gérard Ribes

TL;DR: This novel NID DM syndrome with reduced pancreatic insulin stores, which is similar to human NIDDM in that it has a significant response to glucose (although abnormal in kinetics) and preserved sensitivity to tolbutamide, may provide a particularly advantageous tool for pharmacological investigations of new insulinotropic agents.

TL;DR: 4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' antidiabetic properties and may be considered as a novel drug with potential interest for the treatment of NIDDM.

TL;DR: It is shown that steroid saponins enhance food consumption and motivation to eat, and reduce plasma cholesterol levels in rats, which resulted in a progressive weight gain in these animals, in contrast to untreated diabetic controls.

TL;DR: It appears that saponins may be implicated, alone or together with diosgenin, in the observed hypocholesterolemic effect of fenugreek seeds in diabetic dogs.

TL;DR: In non-insulin-dependent diabetic (NIDD) rats, a single intravenous administration of 4-OH-Ile partially restored glucose-induced insulin response without affecting glucose tolerance; a 6-day subchronic administration of4-OH -Ile reduced basal hyperglycemia, decreased basal insulinemia, and slightly, but significantly, improved glucose tolerance.