R
René Gross
Researcher at Centre national de la recherche scientifique
Publications - 74
Citations - 3391
René Gross is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Insulin & Glucagon. The author has an hindex of 25, co-authored 74 publications receiving 3189 citations. Previous affiliations of René Gross include University of Montpellier.
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Journal ArticleDOI
Experimental NIDDM: Development of a New Model in Adult Rats Administered Streptozotocin and Nicotinamide
Pellegrino Masiello,Christophe Broca,René Gross,M. Roye,M. Manteghetti,Dominique Hillaire-Buys,Michela Novelli,Gérard Ribes +7 more
TL;DR: This novel NID DM syndrome with reduced pancreatic insulin stores, which is similar to human NIDDM in that it has a significant response to glucose (although abnormal in kinetics) and preserved sensitivity to tolbutamide, may provide a particularly advantageous tool for pharmacological investigations of new insulinotropic agents.
Journal ArticleDOI
4-Hydroxyisoleucine: A Novel Amino Acid Potentiator of Insulin Secretion
Yves Sauvaire,Pierre Petit,Christophe Broca,M. Manteghetti,Yves Baissac,Josepha Fernandez-Alvarez,René Gross,M. Roye,Agnès Leconte,Ramon Gomis,Gérard Ribes +10 more
TL;DR: 4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' antidiabetic properties and may be considered as a novel drug with potential interest for the treatment of NIDDM.
Journal ArticleDOI
Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway
E. Youl,G. Bardy,R. Magous,Gérard Cros,F. Sejalon,Anne Virsolvy,Sylvain Richard,Jean-François Quignard,René Gross,Pierre Petit,D. Bataille,Catherine Oiry +11 more
TL;DR: Quercetin lowers plasma glucose, normalizes glucose tolerance tests and preserves pancreatic β‐cell integrity in diabetic rats and activation of the extracellular signal‐regulated kinase (ERK)1/2 pathway was analysed.
Journal ArticleDOI
4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties
Christophe Broca,René Gross,Pierre Petit,Yves Sauvaire,M. Manteghetti,Michel Tournier,Pellegrino Masiello,Ramon Gomis,Gérard Ribes +8 more
TL;DR: In non-insulin-dependent diabetic (NIDD) rats, a single intravenous administration of 4-OH-Ile partially restored glucose-induced insulin response without affecting glucose tolerance; a 6-day subchronic administration of4-OH -Ile reduced basal hyperglycemia, decreased basal insulinemia, and slightly, but significantly, improved glucose tolerance.
Journal ArticleDOI
4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion
Christophe Broca,M. Manteghetti,René Gross,Yves Baissac,Marc Jacob,Pierre Petit,Yves Sauvaire,Gérard Ribes +7 more
TL;DR: The insulinotropic properties of 4-hydroxyisoleucine, in the micromolar range, are seen only in the presence of the linear major isoform; they also require carbon alpha in S-configuration, full methylation and carbon gamma-hydroxylation.