G
Gerdy B. ten Dam
Researcher at Radboud University Nijmegen Medical Centre
Publications - 34
Citations - 2069
Gerdy B. ten Dam is an academic researcher from Radboud University Nijmegen Medical Centre. The author has contributed to research in topics: Heparan sulfate & Epitope. The author has an hindex of 28, co-authored 34 publications receiving 1896 citations. Previous affiliations of Gerdy B. ten Dam include Radboud University Nijmegen.
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Journal ArticleDOI
Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia.
Francesca Properzi,Daniela Carulli,Richard A. Asher,Elizabeth M. Muir,Luiz M Camargo,Toin H. van Kuppevelt,Gerdy B. ten Dam,Yoko Furukawa,Tadishima Mikami,Kazuyuki Sugahara,Toshihiko Toida,Herbert M. Geller,James W. Fawcett +12 more
TL;DR: The results suggest that the up‐regulation of CSPG after CNS injury is associated with a specific sulphation pattern on CS‐GAGs, mediating the inhibitory properties of proteoglycans on axonal regeneration.
Journal ArticleDOI
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.
William C. Lamanna,William C. Lamanna,Rebecca J. Baldwin,Michael Padva,Ina Kalus,Gerdy B. ten Dam,Toin H. van Kuppevelt,John T. Gallagher,Kurt von Figura,Thomas Dierks,Catherine L.R. Merry +10 more
TL;DR: Structural analysis and Mitogenesis assays with FGF2 revealed that Sulf activity decreases the activating potential of newly-synthesized HS, suggesting an important role for these enzymes in cell growth regulation in embryonic and adult tissues.
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Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells.
Claire E. Johnson,Brett E. Crawford,Marios P. Stavridis,Gerdy B. ten Dam,Annie L Wat,Graham Rushton,Christopher M. Ward,Valerie Wilson,Toin H. van Kuppevelt,Jeffrey D. Esko,Austin Smith,John T. Gallagher,Catherine L.R. Merry +12 more
TL;DR: It is suggested that the stage‐specific activities of many of the protein effectors implicated in pluripotency and differentiation are finely regulated by dynamic changes in sulfation motifs in HS chains.
Journal ArticleDOI
Antibody GD3G7 Selected against Embryonic Glycosaminoglycans Defines Chondroitin Sulfate-E Domains Highly Up-Regulated in Ovarian Cancer and Involved in Vascular Endothelial Growth Factor Binding
Gerdy B. ten Dam,Els M.A. van de Westerlo,Anurag Purushothaman,Radu V. Stan,Johan Bulten,Fred C.G.J. Sweep,Leon F.A.G. Massuger,Kazuyuki Sugahara,Toin H. van Kuppevelt +8 more
TL;DR: Rare CS-E-like structures that were strongly expressed in ovarian adenocarcinomas were identified by antibody GD3G7, which might implicate a role forCS-E in VEGF biology, and Vascular endothelial growth factor (VEGF)-sensitive fenestrated and tumor blood vessels were both identified by antibodies.
Journal ArticleDOI
3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.
Gerdy B. ten Dam,Sindhulakshmi Kurup,Els M.A. van de Westerlo,Elly M. M. Versteeg,Ulf Lindahl,Dorothe Spillmann,Toin H. van Kuppevelt +6 more
TL;DR: Antibody HS4C3 selectively detects 3-O-sulfated HS structures and interferes with the coagulation activities of heparin by association with the anti-thrombin binding pentasaccharide sequence.