G
Ghanashyam D. Ghadge
Researcher at University of Chicago
Publications - 50
Citations - 2298
Ghanashyam D. Ghadge is an academic researcher from University of Chicago. The author has contributed to research in topics: Virus & SOD1. The author has an hindex of 24, co-authored 48 publications receiving 2171 citations. Previous affiliations of Ghanashyam D. Ghadge include National Chemical Laboratory & Northwestern University.
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Journal ArticleDOI
Mutant Superoxide Dismutase-1-Linked Familial Amyotrophic Lateral Sclerosis: Molecular Mechanisms of Neuronal Death and Protection
Ghanashyam D. Ghadge,Jean Pyo Lee,Vytautas P. Bindokas,Joaquín Jordán,L. Ma,Richard J. Miller,Raymond P. Roos +6 more
TL;DR: The hypothesis that mutant SOD induced-neurodegeneration is associated with disturbances of neuronal free radical homeostasis is supported by the results.
Journal Article
Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.
Jochen H. M. Prehn,Vytautas P. Bindokas,Joaquín Jordán,Maria F. Galindo,Ghanashyam D. Ghadge,Raymond P. Roos,Lawrence H. Boise,Craig B. Thompson,Stanislaw Krajewski,John C. Reed,Richard J. Miller +10 more
TL;DR: It is found that A beta neurotoxicity was significantly attenuated by single treatments with TGF-beta 1 and prevented by repetitive treatments, and the protective effects of TGF -beta 1 were associated with a preservation of mitochondrial potential and function, as determined with rhodamine-123-based microfluorimetry.
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p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures
Joaquín Jordán,Maria F. Galindo,Jochen H. M. Prehn,Ralph R. Weichselbaum,Michael A. Beckett,Ghanashyam D. Ghadge,Raymond P. Roos,Jeffrey M. Leiden,Richard J. Miller +8 more
TL;DR: It is shown that overexpression of p53 using an adenoviral vector in cultured rat hippocampal pyramidal neurons causes widespread neuronal death with features typical of apoptosis, consistent with a role for p53 in nerve cell death that is distinct from its actions relating to cell cycle arrest.
Journal ArticleDOI
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
Conrad C. Weihl,Ghanashyam D. Ghadge,Scott Kennedy,Nissim Hay,Richard J. Miller,Raymond P. Roos +5 more
TL;DR: Downregulation of Akt/PKB may be a mechanism by which mutant PS1 induces apoptosis and may play a role in the pathogenesis of familial AD.
Journal Article
CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses.
Ghanashyam D. Ghadge,Raymond P. Roos,Un Jung Kang,Robert L. Wollmann,P S Fishman,A M Kalynych,Eliav Barr,Jeffrey M. Leiden +7 more
TL;DR: It is demonstrated that intramuscular injection of replication-defective recombinant adenovirus results in high-level recombinant gene expression, specifically in the CNS motor and sensory neurons that innervate the inoculated muscles.