Ghanshyam N. Pandey

TL;DR: The selective down-regulation of RELN and GAD(67) in prefrontal cortex of patients with schizophrenia and bipolar disorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis; this plus the loss of the correlation between these 2 parameters that exists in nonpsychotic subjects support the hypotheses that these changes may be liability factors underlying psychosis.

TL;DR: Findings of reduced expression of BDNF and trk B in postmortem brain in suicide subjects suggest that these molecules may play an important role in the pathophysiological aspects of suicidal behavior.

TL;DR: In all of the brain areas studied, RELN and its mRNA were significantly reduced in patients with schizophrenia; this decrease was similar in patients affected by undifferentiated or paranoid schizophrenia and is interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia.

TL;DR: An important role for IL-1β, IL-6, and TNF-α in the pathophysiology of suicidal behavior is suggested and that proinflammatory cytokines may be an appropriate target for developing therapeutic agents are suggested.

TL;DR: The evidence indicates higher levels of 5-HT(2A) receptor, protein, and mRNA expression in the prefrontal cortex and hippocampus, which have been implicated in emotion, stress, and cognition, are shown to be associated with teenage suicide.