G
Giampaolo Manao
Researcher at University of Florence
Publications - 73
Citations - 2747
Giampaolo Manao is an academic researcher from University of Florence. The author has contributed to research in topics: Acylphosphatase & Protein tyrosine phosphatase. The author has an hindex of 30, co-authored 73 publications receiving 2637 citations.
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Journal ArticleDOI
The Inactivation Mechanism of Low Molecular Weight Phosphotyrosine-protein Phosphatase by H2O2
Anna Caselli,Riccardo Marzocchini,Guido Camici,Giampaolo Manao,Gloriano Moneti,Giuseppe Pieraccini,Giampietro Ramponi +6 more
TL;DR: It is suggested that oxidative stress conditions and other processes producing hydrogen peroxide regulate the LMW-PTP in thecell, because a physiological concentration of H2O2 produces enzyme inactivation and considering that the activity is restored by reduction with low molecular weight thiols.
Journal ArticleDOI
Purification, characterization, and amino acid sequence of cerato-platanin, a new phytotoxic protein from Ceratocystis fimbriata f. sp. platani.
TL;DR: A new phytotoxic protein (cerato-platanin) of about 12.4 kDa has been identified in culture filtrates of the Ascomycete Ceratocystis fimbriata f.
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Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis.
Alina De Donatis,Giusy Comito,Francesca Buricchi,Maria Cristina Vinci,Astrid Parenti,Anna Caselli,Guido Camici,Giampaolo Manao,Giampietro Ramponi,Paolo Cirri +9 more
TL;DR: The results suggest a mechanism by which cells switch from a migrating to a proliferating phenotype sensing the increasing gradient of PDGF, and propose that the cell decision to proliferate or migrate relies on different endocytotic routes of the PDGF receptor in response to different PDGF concentrations.
Journal ArticleDOI
LMW-PTP is a negative regulator of insulin-mediated mitotic and metabolic signalling.
Paola Chiarugi,Paolo Cirri,Fabio Marra,Giovanni Raugei,Guido Camici,Giampaolo Manao,Giampietro Ramponi +6 more
TL;DR: It is suggested that LMW-PTP acts as a negative regulator of both mitogenetic and metabolic insulin signalling through a pathway involving c-Src kinase but independent by both PI3K and ERK.
Journal ArticleDOI
5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.
Rosanna Maccari,Paolo De Paoli,Rosaria Ottanà,Michela Jacomelli,Rosella Ciurleo,Giampaolo Manao,Theodora M. Steindl,Thierry Langer,Maria Gabriella Vigorita,Guido Camici +9 more
TL;DR: Four 4-Arylidene-2,4-dioxothiazolidin-3-yl)methylbenzoic acids were synthesized and evaluated in vitro as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases which act as negative regulators of the metabolic and mitotic signalling of insulin.