Giampaolo Manao

TL;DR: It is suggested that oxidative stress conditions and other processes producing hydrogen peroxide regulate the LMW-PTP in thecell, because a physiological concentration of H2O2 produces enzyme inactivation and considering that the activity is restored by reduction with low molecular weight thiols.

TL;DR: A new phytotoxic protein (cerato-platanin) of about 12.4 kDa has been identified in culture filtrates of the Ascomycete Ceratocystis fimbriata f.

TL;DR: The results suggest a mechanism by which cells switch from a migrating to a proliferating phenotype sensing the increasing gradient of PDGF, and propose that the cell decision to proliferate or migrate relies on different endocytotic routes of the PDGF receptor in response to different PDGF concentrations.

TL;DR: It is suggested that LMW-PTP acts as a negative regulator of both mitogenetic and metabolic insulin signalling through a pathway involving c-Src kinase but independent by both PI3K and ERK.

TL;DR: Four 4-Arylidene-2,4-dioxothiazolidin-3-yl)methylbenzoic acids were synthesized and evaluated in vitro as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases which act as negative regulators of the metabolic and mitotic signalling of insulin.