G
Gianluca Schiavoni
Researcher at University of Perugia
Publications - 21
Citations - 1622
Gianluca Schiavoni is an academic researcher from University of Perugia. The author has contributed to research in topics: Leukemia & Hairy cell leukemia. The author has an hindex of 11, co-authored 17 publications receiving 1364 citations.
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Journal ArticleDOI
BRAF mutations in hairy-cell leukemia
Enrico Tiacci,Vladimir Trifonov,Gianluca Schiavoni,Antony B. Holmes,Wolfgang Kern,Maria Paola Martelli,Alessandra Pucciarini,Barbara Bigerna,Roberta Pacini,Victoria A. Wells,Paolo Sportoletti,Valentina Pettirossi,Roberta Mannucci,Oliver Elliott,Arcangelo Liso,Achille Ambrosetti,Alessandro Pulsoni,Francesco Forconi,Livio Trentin,Gianpietro Semenzato,Giorgio Inghirami,Monia Capponi,Francesco Di Raimondo,Caterina Patti,Luca Arcaini,Pellegrino Musto,Stefano Pileri,Claudia Haferlach,Susanne Schnittger,Giovanni Pizzolo,Robin Foà,Laurent Farinelli,Torsten Haferlach,Laura Pasqualucci,Raul Rabadan,Brunangelo Falini +35 more
TL;DR: The BRAF V600E mutation was present in all patients with HCL who were evaluated, and may have implications for the pathogenesis, diagnosis, and targeted therapy of HCL.
Journal ArticleDOI
Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation
Enrico Tiacci,Gianluca Schiavoni,Francesco Forconi,Alessia Santi,Livio Trentin,Achille Ambrosetti,Debora Cecchini,Elisa Sozzi,Paola Francia di Celle,Cristiana Di Bello,Alessandro Pulsoni,Robin Foà,Giorgio Inghirami,Brunangelo Falini +13 more
TL;DR: A new, simple, and inexpensive test for genetics-based diagnosis of HCL in whole-blood samples that detects BRAF-V600E through a sensitive allele-specific PCR qualitative assay followed by agarose-gel electrophoresis is described.
Journal ArticleDOI
Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma
Enrico Tiacci,Erik Ladewig,Gianluca Schiavoni,Alex Penson,Elisabetta Fortini,Valentina Pettirossi,Yuchun Wang,Ariele Rosseto,Alessandra Venanzi,Sofija Vlasevska,Roberta Pacini,Simonetta Piattoni,Alessia Tabarrini,Alessandra Pucciarini,Barbara Bigerna,Alessia Santi,Alessandro M. Gianni,Simonetta Viviani,Antonello Cabras,Stefano Ascani,Barbara Crescenzi,Cristina Mecucci,Laura Pasqualucci,Raul Rabadan,Brunangelo Falini +24 more
TL;DR: Overall, 87% of cases showed dysregulation of the JAK-STAT pathway by genetic alterations in multiple genes, attesting to the pivotal role of this pathway in cHL pathogenesis and highlighting its potential as a new therapeutic target in this disease.
Journal ArticleDOI
BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity
Valentina Pettirossi,Alessia Santi,Elisa Imperi,Guido Russo,Alessandra Pucciarini,Barbara Bigerna,Gianluca Schiavoni,Elisabetta Fortini,Ariele Spanhol-Rosseto,Paolo Sportoletti,Roberta Mannucci,Maria Paola Martelli,Ludger Klein-Hitpass,Brunangelo Falini,Enrico Tiacci +14 more
TL;DR: The results strongly support and inform the clinical use of BRAF and MEK inhibitors in HCL and investigate the biological and therapeutic importance of the activated BRAF-mitogen-activated protein kinase kinase Kinase (MEK)-extracellular signal-regulated kinase (ERK) pathway.
Journal ArticleDOI
Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia
Enrico Tiacci,Gianluca Schiavoni,Maria Paola Martelli,Emanuela Boveri,Roberta Pacini,Alessia Tabarrini,Silvia Zibellini,Alessia Santi,Valentina Pettirossi,Elisabetta Fortini,Stefano Ascani,Luca Arcaini,Giorgio Inghirami,Marco Paulli,Brunangelo Falini +14 more
TL;DR: The findings support the use of phospho-ERK immunohistochemistry in the differential diagnosis between hairy cell leukemia and its mimics, and establish the MEK- ERK pathway as a rational therapeutic target in this malignancy.