E
Erik Ladewig
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 22
Citations - 2074
Erik Ladewig is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & FOXA1. The author has an hindex of 13, co-authored 17 publications receiving 1572 citations. Previous affiliations of Erik Ladewig include Columbia University & Kettering University.
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Journal ArticleDOI
Clonal evolution of glioblastoma under therapy.
Jiguang Wang,Emanuela Cazzato,Erik Ladewig,Veronique Frattini,Daniel I. S. Rosenbloom,Sakellarios Zairis,Francesco Abate,Zhaoqi Liu,Oliver Elliott,Yong Jae Shin,Jin Ku Lee,In-Hee Lee,Woong-Yang Park,Marica Eoli,Andrew J. Blumberg,Anna Lasorella,Do-Hyun Nam,Do-Hyun Nam,Gaetano Finocchiaro,Antonio Iavarone,Raul Rabadan +20 more
TL;DR: In recurrent GBM with wild-type IDH1, high LTBP4 expression is associated with worse prognosis, highlighting the TGF-β pathway as a potential therapeutic target in GBM.
Journal ArticleDOI
Comparative analysis of the transcriptome across distant species
Mark Gerstein,Joel Rozowsky,Koon-Kiu Yan,Daifeng Wang,Chao Cheng,James B. Brown,James B. Brown,Carrie A. Davis,LaDeana W. Hillier,Cristina Sisu,Jingyi Jessica Li,Jingyi Jessica Li,Baikang Pei,Arif Harmanci,Michael O. Duff,Sarah Djebali,Roger P. Alexander,Burak H. Alver,Raymond K. Auerbach,Kimberly Bell,Peter J. Bickel,Max E. Boeck,Nathan Boley,Nathan Boley,Benjamin W. Booth,Lucy Cherbas,Peter Cherbas,Chao Di,Alexander Dobin,Jorg Drenkow,Brent Ewing,Gang Fang,Megan Fastuca,Elise A. Feingold,Adam Frankish,Guanjun Gao,Peter J. Good,Roderic Guigó,Ann S. Hammonds,Jen Harrow,Roger A. Hoskins,Cédric Howald,Cédric Howald,Long Hu,Haiyan Huang,Tim Hubbard,Tim Hubbard,Chau Huynh,Sonali Jha,Dionna M. Kasper,Masaomi Kato,Thomas C. Kaufman,Robert R. Kitchen,Erik Ladewig,Julien Lagarde,Eric C. Lai,Jing Leng,Zhi Lu,Michael J. MacCoss,Gemma E. May,Gemma E. May,Rebecca McWhirter,Gennifer E. Merrihew,David M. Miller,Ali Mortazavi,Rabi Murad,Brian Oliver,Sara Olson,Peter J. Park,Michael J. Pazin,Norbert Perrimon,Norbert Perrimon,Dmitri D. Pervouchine,Valerie Reinke,Alexandre Reymond,Garrett Robinson,Anastasia Samsonova,Anastasia Samsonova,Gary Saunders,Gary Saunders,Felix Schlesinger,Anurag Sethi,Frank J. Slack,William C. Spencer,Marcus H. Stoiber,Marcus H. Stoiber,Pnina Strasbourger,Andrea Tanzer,Andrea Tanzer,Owen Thompson,Kenneth H. Wan,Guilin Wang,Huaien Wang,Kathie L. Watkins,Jiayu Wen,Kejia Wen,Chenghai Xue,Li Yang,Li Yang,Kevin Y. Yip,Chris Zaleski,Yan Zhang,Henry Zheng,Steven E. Brenner,Brenton R. Graveley,Susan E. Celniker,Thomas R. Gingeras,Robert H. Waterston +107 more
TL;DR: It is found in all three organisms that the gene-expression levels, both coding and non-coding, can be quantitatively predicted from chromatin features at the promoter using a ‘universal model’ based on a single set of organism-independent parameters.
Journal ArticleDOI
Spatiotemporal Genomic Architecture Informs Precision Oncology in Glioblastoma
Jin Ku Lee,Jiguang Wang,Jiguang Wang,Jason K. Sa,Jason K. Sa,Erik Ladewig,Hae Ock Lee,In-Hee Lee,Hyun Ju Kang,Daniel I. S. Rosenbloom,Pablo G. Camara,Zhaoqi Liu,Patrick Van Nieuwenhuizen,Sang Won Jung,Sang Won Jung,Seung Won Choi,Seung Won Choi,Jun Hyung Kim,Andrew X. Chen,Kyu-Tae Kim,Sang Shin,Sang Shin,Yun Jee Seo,Jin Mi Oh,Yong Jae Shin,Chul-Kee Park,Doo Sik Kong,Ho Jun Seol,Andrew J. Blumberg,Jung Il Lee,Antonio Iavarone,Woong-Yang Park,Woong-Yang Park,Raul Rabadan,Do-Hyun Nam,Do-Hyun Nam +35 more
TL;DR: It is shown that evolutionary inference from integrated genomic analysis in multisector biopsies can inform targeted therapeutic interventions for patients with GBM and that targeting truncal events is more efficacious than targeting private events in reducing the tumor burden.
Journal ArticleDOI
Discovery of hundreds of mirtrons in mouse and human small RNA data
Erik Ladewig,Katsutomo Okamura,Katsutomo Okamura,Alex S. Flynt,Jakub Orzechowski Westholm,Eric C. Lai +5 more
TL;DR: The recognition of hundreds of mammalian mirtrons provides a new foundation for understanding the scope and evolutionary dynamics of Dicer substrates in mammals and provides the first Northern validation for mammalian mirTrons.
Journal ArticleDOI
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Neil Vasan,Neil Vasan,Pedram Razavi,Jared L. Johnson,Hong Shao,Hardik Shah,Alesia Antoine,Erik Ladewig,Alexander N. Gorelick,Ting-Yu Lin,Eneda Toska,Guotai Xu,Abiha Kazmi,Matthew T. Chang,Barry S. Taylor,Maura N. Dickler,Maura N. Dickler,Komal Jhaveri,Sarat Chandarlapaty,Raul Rabadan,Ed Reznik,Melissa Smith,Robert Sebra,Frauke Schimmoller,Timothy R. Wilson,Lori Friedman,Lewis C. Cantley,Maurizio Scaltriti,José Baselga +28 more
TL;DR: Preliminary analysis of clinical trial data suggests that breast cancers with double mutations are more responsive to PI3K inhibitors than those with a single mutation, and PIK3CA mutational status could help identify the breast cancer patients most likely to benefit from these drugs.