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Barbara Bigerna
Researcher at University of Perugia
Publications - 49
Citations - 6306
Barbara Bigerna is an academic researcher from University of Perugia. The author has contributed to research in topics: Nucleophosmin & Germinal center. The author has an hindex of 29, co-authored 46 publications receiving 5805 citations. Previous affiliations of Barbara Bigerna include European Institute of Oncology.
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Journal ArticleDOI
Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
Brunangelo Falini,Christina Mecucci,Enrico Tiacci,Myriam Alcalay,Roberto Rosati,Laura Pasqualucci,Roberta La Starza,Daniela Diverio,Emanuela Colombo,Antonella Santucci,Barbara Bigerna,Roberta Pacini,Alessandra Pucciarini,Arcangelo Liso,Marco Vignetti,Paola Fazi,Natalia Meani,Valentina Pettirossi,Giuseppe Saglio,Franco Mandelli,Francesco Lo-Coco,Pier Giuseppe Pelicci,Massimo F. Martelli +22 more
TL;DR: Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.
Journal ArticleDOI
BRAF mutations in hairy-cell leukemia
Enrico Tiacci,Vladimir Trifonov,Gianluca Schiavoni,Antony B. Holmes,Wolfgang Kern,Maria Paola Martelli,Alessandra Pucciarini,Barbara Bigerna,Roberta Pacini,Victoria A. Wells,Paolo Sportoletti,Valentina Pettirossi,Roberta Mannucci,Oliver Elliott,Arcangelo Liso,Achille Ambrosetti,Alessandro Pulsoni,Francesco Forconi,Livio Trentin,Gianpietro Semenzato,Giorgio Inghirami,Monia Capponi,Francesco Di Raimondo,Caterina Patti,Luca Arcaini,Pellegrino Musto,Stefano Pileri,Claudia Haferlach,Susanne Schnittger,Giovanni Pizzolo,Robin Foà,Laurent Farinelli,Torsten Haferlach,Laura Pasqualucci,Raul Rabadan,Brunangelo Falini +35 more
TL;DR: The BRAF V600E mutation was present in all patients with HCL who were evaluated, and may have implications for the pathogenesis, diagnosis, and targeted therapy of HCL.
Journal ArticleDOI
A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
Brunangelo Falini,Marco Fizzotti,Alessandra Pucciarini,Barbara Bigerna,Teresa Marafioti,Marcello Gambacorta,Roberta Pacini,Cristina Alunni,Laura Natali-Tanci,Barbara Ugolini,Carla Sebastiani,Giorgio Cattoretti,Stefano Pileri,Riccardo Dalla-Favera,Harald Stein +14 more
TL;DR: The results suggest that MUM1 is involved in the late stages of B-cell differentiation and in T-cell activation and is deregulated in DLCL-B.
Journal ArticleDOI
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance.
Myriam Alcalay,Enrico Tiacci,Roberta Bergomas,Barbara Bigerna,Elisa Venturini,Simone Minardi,Natalia Meani,Daniela Diverio,Loris Bernard,Laura Tizzoni,Sara Volorio,Lucilla Luzi,Emanuela Colombo,Francesco Lo Coco,Cristina Mecucci,B. Falini,Pier Giuseppe Pelicci +16 more
TL;DR: The molecular signature of NPMc+ AML includes up-regulation of several genes putatively involved in the maintenance of a stem-cell phenotype, suggesting that NPM c- AML may derive from a multipotent hematopoietic progenitor.
Journal Article
PG-M1: A new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule
Brunangelo Falini,L. Flenghi,Stefano Pileri,Marcello Gambacorta,Barbara Bigerna,Horst Dürkop,F Eitelbach,Juergen Thiele,Roberta Pacini,A Cavaliere +9 more
TL;DR: A new anti-macrophage monoclonal antibody was produced by immunizing BALB/c mice with fresh spleen cells from a patient with Gaucher's disease, and the reactivity of the antibody with COS-1 and WOP cells transfected with a human complementary DNA clone encoding for the CD68 antigen suggests that PG-M1 is a new member of theCD68 cluster.