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Gianluigi Veglia
Researcher at University of Minnesota
Publications - 221
Citations - 8287
Gianluigi Veglia is an academic researcher from University of Minnesota. The author has contributed to research in topics: Phospholamban & Solid-state nuclear magnetic resonance. The author has an hindex of 51, co-authored 211 publications receiving 7417 citations. Previous affiliations of Gianluigi Veglia include Stony Brook University & Florida State University.
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Journal ArticleDOI
Direct Observation of the Three Regions in α-Synuclein that Determine its Membrane-Bound Behaviour
Giuliana Fusco,Alfonso De Simone,Tata Gopinath,Vitaly V. Vostrikov,Michele Vendruscolo,Christopher M. Dobson,Gianluigi Veglia +6 more
TL;DR: A combination of solid-state and solution-state NMR spectroscopy is used to characterize the conformations of αS bound to lipid membranes mimicking the composition and physical properties of synaptic vesicles and provide insights into their roles in the function and in the molecular processes leading the aggregation.
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Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz
Peter L. Gor’kov,Eduard Y. Chekmenev,Eduard Y. Chekmenev,Conggang Li,Myriam Cotten,Jarrod J. Buffy,Nathaniel J. Traaseth,Gianluigi Veglia,William W. Brey +8 more
TL;DR: This work describes specially designed, large volume, low-E 15N-1H solid-state NMR probes developed for 600 and 900 MHz PISEMA studies of dilute membrane proteins oriented in hydrated and dielectrically lossy lipid bilayers using an orthogonal coil design.
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Structural basis of synaptic vesicle assembly promoted by α-synuclein
Giuliana Fusco,Tillmann Pape,Amberley D. Stephens,Pierre Mahou,Pierre Mahou,Ana Rita Costa,Clemens F. Kaminski,Gabriele S. Kaminski Schierle,Michele Vendruscolo,Gianluigi Veglia,Christopher M. Dobson,Alfonso De Simone +11 more
TL;DR: The analysis of wild-type αS and two mutational variants linked to familial Parkinson's disease are reported to describe the structural basis of a molecular mechanism enabling αS to induce the clustering of synaptic vesicles.
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Dynamics connect substrate recognition to catalysis in protein kinase A
Larry R. Masterson,Cecilia Y. Cheng,Tao Yu,Marco Tonelli,Alexandr P. Kornev,Susan S. Taylor,Gianluigi Veglia +6 more
TL;DR: The results show that the enzyme toggles between open and closed states, which indicates that a conformational selection rather than an induced-fit mechanism governs substrate recognition.
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Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach
Nathaniel J. Traaseth,Lei Shi,Raffaello Verardi,Daniel G. Mullen,George Barany,Gianluigi Veglia +5 more
TL;DR: The high-resolution structure and topology of the T state of a monomeric PLN mutant in lipid bilayers is reported, using a hybrid of solution and solid-state NMR restraints together with molecular dynamics simulations in explicit lipid environments.