M
Myriam Cotten
Researcher at College of William & Mary
Publications - 49
Citations - 1395
Myriam Cotten is an academic researcher from College of William & Mary. The author has contributed to research in topics: Lipid bilayer & Gramicidin. The author has an hindex of 21, co-authored 46 publications receiving 1200 citations. Previous affiliations of Myriam Cotten include Florida State University & Hamilton College.
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Journal ArticleDOI
Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz
Peter L. Gor’kov,Eduard Y. Chekmenev,Eduard Y. Chekmenev,Conggang Li,Myriam Cotten,Jarrod J. Buffy,Nathaniel J. Traaseth,Gianluigi Veglia,William W. Brey +8 more
TL;DR: This work describes specially designed, large volume, low-E 15N-1H solid-state NMR probes developed for 600 and 900 MHz PISEMA studies of dilute membrane proteins oriented in hydrated and dielectrically lossy lipid bilayers using an orthogonal coil design.
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Noncontact Dipole Effects on Channel Permeation. I. Experiments with (5F-Indole)Trp13 Gramicidin A Channels
David D. Busath,Craig D. Thulin,Richard W. Hendershot,L. Revell Phillips,Peter J. Maughan,Chad D. Cole,Nathan C. Bingham,Sara E. Morrison,Lissa C. Baird,Reed Jacob Hendershot,Myriam Cotten,Timothy A. Cross +11 more
TL;DR: Observations indicate that fluorination does not change the rotameric conformation of the side chain, and Eadie-Hofstee plot slopes suggest similar destabilization of K+ binding in both lipids.
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Investigating molecular recognition and biological function at interfaces using piscidins, antimicrobial peptides from fish.
Eduard Y. Chekmenev,Breanna S. Vollmar,Kristen T. Forseth,McKenna N. Manion,Shiela M. Jones,Tim J. Wagner,RaeLynn M. Endicott,Brandon Kyriss,Lorraine M. Homem,Michelle Pate,Jing He,Joshua Raines,Peter L. Gor’kov,William W. Brey,Dan J. Mitchell,Ann J. Auman,Mary J. Ellard-Ivey,Jack Blazyk,Myriam Cotten +18 more
TL;DR: It is proposed that piscidin 1 and 3's topology and fast dynamics are related to their mechanism of action as well as the structural motifs involved in biological activity and functional diversity among amidated and non-amidated isoforms.
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High-Resolution Structures and Orientations of Antimicrobial Peptides Piscidin 1 and Piscidin 3 in Fluid Bilayers Reveal Tilting, Kinking, and Bilayer Immersion
B. Scott Perrin,Ye Tian,Riqiang Fu,Christopher V. Grant,Eduard Y. Chekmenev,William E. Wieczorek,Alexander E. Dao,Robert M. Hayden,Caitlin M. Burzynski,Richard M. Venable,Mukesh Sharma,Stanley J. Opella,Richard W. Pastor,Myriam Cotten +13 more
TL;DR: Structural refinement of 1H–15N dipolar couplings and 15N chemical shifts measured by oriented sample solid-state NMR and all-atom molecular dynamics simulations provide structural and orientational information of high precision and accuracy about these interfacially bound α-helical peptides.
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Nuclease Activity Gives an Edge to Host-Defense Peptide Piscidin 3 over Piscidin 1, Rendering it more Effective against Persisters and Biofilms
M. Daben J. Libardo,Ali Adem Bahar,Buyong Ma,Riqiang Fu,Laura E. McCormick,Jun Zhao,Scott A. McCallum,Ruth Nussinov,Ruth Nussinov,Dacheng Ren,Alfredo M. Angeles-Boza,Myriam Cotten +11 more
TL;DR: It is demonstrated that the N‐termini of both peptides coordinate Cu2+ and p3‐Cu cleaves isolated DNA at a rate on par with free Cu2 + but significantly faster than p1‐Cu, which is commensurate with stronger peptide‐induced DNA damage.