Gilles Naeije

TL;DR: It is shown that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons.

TL;DR: Postmortem brain MRI demonstrates hemorrhagic and PRES-related brain lesions in non-survivors of COVID-19, and brainstem MRI findings do not support a brain-related contribution to respiratory distress in CO VID-19.

TL;DR: A method by which millions of cortical neurons can be generated in 2–3 weeks, starting from a single frozen vial of ESCs is described, opening new perspectives for the modeling of cortical diseases and the design of novel neurological treatments, while offering an alternative to animal use.

TL;DR: cEEG can identify patients with poor outcome from the first hours following CA, with limited predictive value for good outcome, but seizures and generalized periodic discharges were associated withpoor outcome even when developing on a benign EEG pattern.

TL;DR: Postmortem brain MRI demonstrates hemorrhagic and PRES-related brain lesions in non-survivors of COVID-19 that might be triggered by the virus-induced endothelial disturbances and the absence of brainstem MRI abnormalities does not support a brain-related contribution to respiratory distress in CO VID-19.