N
Nicolas Gaspard
Researcher at Université libre de Bruxelles
Publications - 160
Citations - 5521
Nicolas Gaspard is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Medicine & Status epilepticus. The author has an hindex of 31, co-authored 126 publications receiving 3992 citations. Previous affiliations of Nicolas Gaspard include Free University of Brussels & Yale University.
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Journal ArticleDOI
An intrinsic mechanism of corticogenesis from embryonic stem cells
Nicolas Gaspard,Tristan Bouschet,Raphael Hourez,Jordane Dimidschstein,Gilles Naeije,Jelle van den Ameele,Ira Espuny-Camacho,Adèle Herpoel,Lara Passante,Serge N. Schiffmann,Afsaneh Gaillard,Pierre Vanderhaeghen +11 more
TL;DR: It is shown that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons.
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Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.
Ira Espuny-Camacho,Kimmo A. Michelsen,David Gall,Daniele Linaro,Anja Hasche,Jérôme Bonnefont,Camilia Bali,David Orduz,Angéline Bilheu,Adèle Herpoel,Nelle Lambert,Nicolas Gaspard,Sophie Péron,Serge N. Schiffmann,Michele Giugliano,Michele Giugliano,Michele Giugliano,Afsaneh Gaillard,Pierre Vanderhaeghen +18 more
TL;DR: The data demonstrate that human cortical neurons generated in vitro from ESC/iPSC can develop complex hodological properties characteristic of the cerebral cortex in vivo, thereby offering unprecedented opportunities for the modeling of human cortex diseases and brain repair.
Journal ArticleDOI
New-onset refractory status epilepticus: Etiology, clinical features, and outcome
Nicolas Gaspard,Nicolas Gaspard,Brandon Foreman,Vincent Alvarez,Vincent Alvarez,Christian M. Cabrera Kang,John C. Probasco,Amy C. Jongeling,Emma Meyers,Alyssa R. Espinera,Kevin F. Haas,Sarah E. Schmitt,Elizabeth E. Gerard,Teneille Gofton,Peter W. Kaplan,Jong W. Lee,Benjamin Legros,Jerzy P. Szaflarski,Brandon Westover,Suzette M. LaRoche,Lawrence J. Hirsch +20 more
TL;DR: Autoimmune encephalitis is the most commonly identified cause of new-onset refractory status epilepticus, but half remain cryptogenic, and outcome at discharge is poor but improves during follow-up.
Journal ArticleDOI
American Clinical Neurophysiology Society's Standardized Critical Care EEG Terminology: 2021 Version.
Lawrence J. Hirsch,Michael W.K. Fong,Markus Leitinger,Suzette M. LaRoche,Sándor Beniczky,Nicholas S. Abend,Jong Woo Lee,Courtney J. Wusthoff,Cecil D. Hahn,M. Brandon Westover,Elizabeth E. Gerard,Susan T. Herman,Hiba A. Haider,Gamaleldin Osman,Andres Rodriguez-Ruiz,Carolina B. Maciel,Emily J. Gilmore,Andres Fernandez,Eric Rosenthal,Jan Claassen,Aatif M. Husain,Ji Yeoun Yoo,Elson L. So,Peter W. Kaplan,Marc R. Nuwer,Michel J.A.M. van Putten,Raoul Sutter,Frank W. Drislane,Eugen Trinka,Nicolas Gaspard +29 more
TL;DR: In the early 2000s, a subcommittee of the American Clinical Neurophysiology Society (ACNS) set out to standardize terminology of periodic and rhythmic EEG patterns in the critically ill to aid in future research involving such patterns as mentioned in this paper.
Journal ArticleDOI
Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions.
Lawrence J. Hirsch,Nicolas Gaspard,Andreas van Baalen,Rima Nabbout,Sophie Demeret,Tobias Loddenkemper,Vincent Navarro,Nicola Specchio,Lieven Lagae,Andrea O. Rossetti,Sara E. Hocker,Teneille Gofton,Nicholas S. Abend,Emily J. Gilmore,Cecil D. Hahn,Houman Khosravani,Houman Khosravani,Felix Rosenow,Eugen Trinka +18 more
TL;DR: An international group of experts were convened to standardize definitions of New‐Onset Refractory Status Epilepticus (NORSE), Febrile Infection‐Related Epilepsy Syndrome (FIRES), and related conditions to enable improved communication for investigators, physicians, families, patients, and other caregivers.