I
Ira Espuny-Camacho
Researcher at University of Milan
Publications - 11
Citations - 1719
Ira Espuny-Camacho is an academic researcher from University of Milan. The author has contributed to research in topics: Induced pluripotent stem cell & Corticogenesis. The author has an hindex of 9, co-authored 10 publications receiving 1470 citations. Previous affiliations of Ira Espuny-Camacho include Université libre de Bruxelles & Katholieke Universiteit Leuven.
Papers
More filters
Journal ArticleDOI
An intrinsic mechanism of corticogenesis from embryonic stem cells
Nicolas Gaspard,Tristan Bouschet,Raphael Hourez,Jordane Dimidschstein,Gilles Naeije,Jelle van den Ameele,Ira Espuny-Camacho,Adèle Herpoel,Lara Passante,Serge N. Schiffmann,Afsaneh Gaillard,Pierre Vanderhaeghen +11 more
TL;DR: It is shown that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons.
Journal ArticleDOI
Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.
Ira Espuny-Camacho,Kimmo A. Michelsen,David Gall,Daniele Linaro,Anja Hasche,Jérôme Bonnefont,Camilia Bali,David Orduz,Angéline Bilheu,Adèle Herpoel,Nelle Lambert,Nicolas Gaspard,Sophie Péron,Serge N. Schiffmann,Michele Giugliano,Michele Giugliano,Michele Giugliano,Afsaneh Gaillard,Pierre Vanderhaeghen +18 more
TL;DR: The data demonstrate that human cortical neurons generated in vitro from ESC/iPSC can develop complex hodological properties characteristic of the cerebral cortex in vivo, thereby offering unprecedented opportunities for the modeling of human cortex diseases and brain repair.
Journal ArticleDOI
Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
Ira Espuny-Camacho,Amaia M. Arranz,Mark Fiers,An Snellinx,Kunie Ando,Sebastian Munck,Jérôme Bonnefont,Laurie Lambot,Nikky Corthout,Lorna Omodho,Elke Vanden Eynden,Enrico Radaelli,Ina Tesseur,Selina Wray,Andreas Ebneth,John Hardy,Karelle Leroy,Jean Pierre Brion,Pierre Vanderhaeghen,Pierre Vanderhaeghen,Bart De Strooper,Bart De Strooper +21 more
TL;DR: This novel chimeric model for AD displays human-specific pathological features and allows the analysis of different genetic backgrounds and mutations during the course of the disease.
Journal ArticleDOI
Area-Specific Reestablishment of Damaged Circuits in the Adult Cerebral Cortex by Cortical Neurons Derived from Mouse Embryonic Stem Cells
Kimmo A. Michelsen,Sandra Acosta-Verdugo,Marianne Benoit-Marand,Ira Espuny-Camacho,Nicolas Gaspard,Bhaskar Saha,Afsaneh Gaillard,Pierre Vanderhaeghen +7 more
TL;DR: It is shown that neurons of visual cortex identity, differentiated in vitro from mouse embryonic stem cells (ESCs), can be transplanted successfully following a lesion of the adult mouse visual cortex.
Journal ArticleDOI
Thinking out of the dish: what to learn about cortical development using pluripotent stem cells
Jelle van den Ameele,Jelle van den Ameele,Luca Tiberi,Pierre Vanderhaeghen,Ira Espuny-Camacho,Ira Espuny-Camacho +5 more
TL;DR: Findings are reviewed with emphasis on the new perspectives that PSC can differentiate into a wide range of cortical neurons in vitro, which can integrate appropriately into the brain following in vivo transplantation.