S
Serge N. Schiffmann
Researcher at Université libre de Bruxelles
Publications - 193
Citations - 15362
Serge N. Schiffmann is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Striatum & Receptor. The author has an hindex of 62, co-authored 189 publications receiving 14278 citations. Previous affiliations of Serge N. Schiffmann include Centre national de la recherche scientifique & Karolinska Institutet.
Papers
More filters
Journal ArticleDOI
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
Journal ArticleDOI
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.
Catherine Ledent,Jean-Marie Vaugeois,Serge N. Schiffmann,Thierry Pedrazzini,Malika El Yacoubi,Jean-Jacques Vanderhaeghen,Jean Costentin,John K. Heath,Gilbert Vassart,Marc Parmentier +9 more
TL;DR: It was found that A2aR-knockout mice were viable and bred normally, and male mice were much more aggressive towards intruders, whereas caffeine, which normally stimulates exploratory behaviour, became a depressant of exploratory activity.
Journal ArticleDOI
An intrinsic mechanism of corticogenesis from embryonic stem cells
Nicolas Gaspard,Tristan Bouschet,Raphael Hourez,Jordane Dimidschstein,Gilles Naeije,Jelle van den Ameele,Ira Espuny-Camacho,Adèle Herpoel,Lara Passante,Serge N. Schiffmann,Afsaneh Gaillard,Pierre Vanderhaeghen +11 more
TL;DR: It is shown that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons.
Journal ArticleDOI
Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.
TL;DR: It is demonstrated that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P‐containing or cholinergic neurons.
Journal ArticleDOI
Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.
Ira Espuny-Camacho,Kimmo A. Michelsen,David Gall,Daniele Linaro,Anja Hasche,Jérôme Bonnefont,Camilia Bali,David Orduz,Angéline Bilheu,Adèle Herpoel,Nelle Lambert,Nicolas Gaspard,Sophie Péron,Serge N. Schiffmann,Michele Giugliano,Michele Giugliano,Michele Giugliano,Afsaneh Gaillard,Pierre Vanderhaeghen +18 more
TL;DR: The data demonstrate that human cortical neurons generated in vitro from ESC/iPSC can develop complex hodological properties characteristic of the cerebral cortex in vivo, thereby offering unprecedented opportunities for the modeling of human cortex diseases and brain repair.