G
Gina M Gallego-Lopez
Researcher at University of Wisconsin-Madison
Publications - 13
Citations - 163
Gina M Gallego-Lopez is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Babesia bovis & Toxoplasma gondii. The author has an hindex of 5, co-authored 10 publications receiving 106 citations. Previous affiliations of Gina M Gallego-Lopez include Morgridge Institute for Research & Washington State University.
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Journal ArticleDOI
Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuation
TL;DR: Investigating the transcriptome profiles of two geographically distinct B. bovis virulent and attenuated strain pairs concluded that ves heterodimer pair upregulation and overall higher frequency of ves gene expressions in the virulent strains is consistent with the involvement of this gene family in virulence.
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Shared elements of host-targeting pathways among apicomplexan parasites of differing lifestyles
Karell G. Pellé,Rays H. Y. Jiang,Rays H. Y. Jiang,Pierre-Yves Mantel,Yu-Ping Xiao,Daisy Hjelmqvist,Gina M Gallego-Lopez,Audrey O.T. Lau,Byung-Ho Kang,David R. Allred,Matthias Marti +10 more
TL;DR: This work functionally demonstrate an analogous host‐targeting pathway involving organellar staging prior to secretion in the related bovine parasite, Babesia bovis, a parasite that destroys the PVM shortly after invasion.
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Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability
William John Olson,Bruno Martorelli Di Genova,Gina M Gallego-Lopez,Gina M Gallego-Lopez,Anthony R. Dawson,David M. Stevenson,Daniel Amador-Noguez,Laura J. Knoll +7 more
TL;DR: Changes in the joint host-parasite metabolome over a time course of infection led to the discovery of a T. gondii enzyme, sedoheptulose bisphosphatase, which funnels carbon from glycolysis into the pentose phosphate pathway through an energetically driven dephosphorylation reaction.
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Up-regulated expression of spherical body protein 2 truncated copy 11 in Babesia bovis is associated with reduced cytoadhesion to vascular endothelial cells.
Gina M Gallego-Lopez,Audrey O.T. Lau,Roberta M. O'Connor,Massaro W. Ueti,Brian M. Cooke,Jacob M. Laughery,Telmo Graça,Sally A. Madsen-Bouterse,Daiane Patrícia Oldiges,David R. Allred,Carlos E. Suarez,Carlos E. Suarez +11 more
TL;DR: Confirmed up-regulation of sbp2t11 in B. bovis concomitant with the reduction of iRBC in vitro cytoadhesion to bovine brain endothelial cell is consistent with the previous finding that up- regulation of s Bryce 2 truncated copy 11 is an attenuation marker in
Journal ArticleDOI
Spherical Body Protein 2 truncated copy 11 as a specific Babesia bovis attenuation marker.
Gina M Gallego-Lopez,Audrey O.T. Lau,Wendy C. Brown,Wendell C. Johnson,Massaro W. Ueti,Massaro W. Ueti,Carlos E. Suarez,Carlos E. Suarez +7 more
TL;DR: Sbp2t11 is a strong candidate as a reliable attenuation marker for B. bovis, based on its consistent pattern of upregulation in four distinct attenuated strains when compared to their virulent parental strains.