G
Giovana Seno Di Marco
Researcher at Federal University of São Paulo
Publications - 37
Citations - 3575
Giovana Seno Di Marco is an academic researcher from Federal University of São Paulo. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 18, co-authored 34 publications receiving 3060 citations. Previous affiliations of Giovana Seno Di Marco include University of Münster.
Papers
More filters
Journal ArticleDOI
FGF23 induces left ventricular hypertrophy
Christian Faul,Ansel P. Amaral,Behzad N. Oskouei,Ming Chang Hu,Alexis Sloan,Tamara Isakova,Orlando M. Gutiérrez,Robier Aguillon-Prada,Joy Lincoln,Joshua M. Hare,Peter Mundel,Azorides R. Morales,Julia J. Scialla,Michael J. Fischer,Michael J. Fischer,Elsayed Z. Soliman,Jing Chen,Alan S. Go,Sylvia E. Rosas,Lisa Nessel,Raymond R. Townsend,Harold I. Feldman,Martin St. John Sutton,Akinlolu O. Ojo,Crystal A. Gadegbeku,Giovana Seno Di Marco,Stefan Reuter,Dominik Kentrup,Klaus Tiemann,Marcus Brand,Joseph A. Hill,Orson W. Moe,Makoto Kuro-o,John W. Kusek,Martin G. Keane,Myles Wolf +35 more
TL;DR: It is reported that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort and suggested that chronically elevated F GF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD.
Journal ArticleDOI
Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy
Alexander Grabner,Ansel P. Amaral,Karla Schramm,Saurav Singh,Alexis Sloan,Christopher Yanucil,Jihe Li,Lina A. Shehadeh,Joshua M. Hare,Valentin David,Valentin David,Aline Martin,Aline Martin,Alessia Fornoni,Giovana Seno Di Marco,Dominik Kentrup,Stefan Reuter,Anna B. Mayer,Hermann Pavenstädt,Jörg Stypmann,Christian Kuhn,Susanne Hille,Norbert Frey,Maren Leifheit-Nestler,Beatrice Richter,Dieter Haffner,Reimar Abraham,Johannes Bange,Bianca Sperl,Axel Ullrich,Marcus Brand,Myles Wolf,Christian Faul +32 more
TL;DR: It is reported that FGF23 exclusively activates FGFR4 on cardiac myocytes to stimulate phospholipase Cγ/calcineurin/nuclear factor of activated T cell signaling and promotes LVH by activatingFGFR4, thereby establishing FGFR 4 as a pharmacological target for reducing cardiovascular risk in CKD.
Journal ArticleDOI
Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease
Saurav Singh,Alexander Grabner,Christopher Yanucil,Karla Schramm,Brian Czaya,Stefanie Krick,Mark J. Czaja,René Bartz,Reimar Abraham,Giovana Seno Di Marco,Marcus Brand,Myles Wolf,Christian Faul +12 more
TL;DR: The findings indicate a novel mechanism of chronic inflammation in patients with CKD and suggest that FGFR4 blockade might have therapeutic anti-inflammatory effects in CKD.
Journal ArticleDOI
Damage of the endothelial glycocalyx in chronic kidney disease
Jan Sören Padberg,Anne Wiesinger,Giovana Seno Di Marco,Stefan Reuter,Alexander Grabner,Dominik Kentrup,Alexander Lukasz,Hans Oberleithner,Hermann Pavenstädt,Marcus Brand,Philipp Kümpers +10 more
TL;DR: Findings provide evidence for damage of the atheroprotective eGC as a consequence of CKD and potentially open a new avenue to pathophysiology and treatment of cardiovascular disease in renal patients.
Journal ArticleDOI
The Soluble VEGF Receptor sFlt1 Contributes to Endothelial Dysfunction in CKD
Giovana Seno Di Marco,Stefan Reuter,Uta Hillebrand,Susanne Amler,Maximilian König,Etienne Larger,Hans Oberleithner,Eva Brand,Hermann Pavenstädt,Marcus Brand +9 more
TL;DR: The findings show that excess sFlt-1 associates with endothelial dysfunction in CKD and suggest that increased sFelt-1 may predict cardiovascular risk in CKC, and identify monocytes as a possible source of increased s Flt1 in patients with CKD.