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Crystal A. Gadegbeku
Researcher at Temple University
Publications - 95
Citations - 7167
Crystal A. Gadegbeku is an academic researcher from Temple University. The author has contributed to research in topics: Kidney disease & Renal function. The author has an hindex of 34, co-authored 81 publications receiving 5426 citations. Previous affiliations of Crystal A. Gadegbeku include University of California, San Francisco & University of Michigan.
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Journal ArticleDOI
FGF23 induces left ventricular hypertrophy
Christian Faul,Ansel P. Amaral,Behzad N. Oskouei,Ming Chang Hu,Alexis Sloan,Tamara Isakova,Orlando M. Gutiérrez,Robier Aguillon-Prada,Joy Lincoln,Joshua M. Hare,Peter Mundel,Azorides R. Morales,Julia J. Scialla,Michael J. Fischer,Michael J. Fischer,Elsayed Z. Soliman,Jing Chen,Alan S. Go,Sylvia E. Rosas,Lisa Nessel,Raymond R. Townsend,Harold I. Feldman,Martin St. John Sutton,Akinlolu O. Ojo,Crystal A. Gadegbeku,Giovana Seno Di Marco,Stefan Reuter,Dominik Kentrup,Klaus Tiemann,Marcus Brand,Joseph A. Hill,Orson W. Moe,Makoto Kuro-o,John W. Kusek,Martin G. Keane,Myles Wolf +35 more
TL;DR: It is reported that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort and suggested that chronically elevated F GF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD.
Journal ArticleDOI
Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease.
Tamara Isakova,Patricia Wahl,Gabriela Vargas,Orlando M. Gutiérrez,Julia J. Scialla,Huiliang Xie,Dina Appleby,Lisa Nessel,Keith Bellovich,Jing Chen,L. Lee Hamm,Crystal A. Gadegbeku,Edward Horwitz,Raymond R. Townsend,Cheryl A.M. Anderson,James P. Lash,Chi-yuan Hsu,Mary B. Leonard,Myles Wolf +18 more
TL;DR: Increased FGF23 is a common manifestation of CKD that develops earlier than increased phosphate or PTH, and may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels.
Journal ArticleDOI
Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function
James P. Lash,Alan S. Go,Lawrence J. Appel,Jiang He,Akinlolu O. Ojo,Mahboob Rahman,Raymond R. Townsend,Dawei Xie,Denise Cifelli,Janet Cohan,Jeffrey C. Fink,Michael J. Fischer,Michael J. Fischer,Crystal A. Gadegbeku,L. Lee Hamm,John W. Kusek,J. Richard Landis,Andrew S. Narva,Nancy Robinson,Valerie Teal,Harold I. Feldman +20 more
TL;DR: Lower level of eGFR was associated with a greater burden of CVD as well as lower socioeconomic and educational status and long-term follow-up of participants will provide critical insights into the epidemiology of CKD and its relationship to adverse outcomes.
Journal ArticleDOI
Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker
Wenjun Ju,Viji Nair,Shahaan Smith,Li Zhu,Kerby Shedden,Peter X.-K. Song,Laura H. Mariani,Felix Eichinger,Celine C. Berthier,Ann Randolph,Jennifer Y. Lai,Yan Zhou,Jennifer Hawkins,Markus Bitzer,Matthew G. Sampson,Martina Thier,Corinne Solier,Gonzalo Duran-Pacheco,Guillemette Duchateau-Nguyen,Laurent Essioux,Brigitte Schott,Ivan Formentini,Maria Chiara Magnone,Maria Bobadilla,Clemens D. Cohen,Serena M. Bagnasco,Laura Barisoni,Jicheng Lv,Hong Zhang,Haiyan Wang,Frank C. Brosius,Crystal A. Gadegbeku,Matthias Kretzler +32 more
TL;DR: The authors demonstrated that the amount of EGF in the urine is just as useful, providing a biomarker that can be easily tracked over time without requiring invasive biopsies, and identified uEGF as an independent risk predictor of CKD progression.
Journal ArticleDOI
Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach
Crystal A. Gadegbeku,Debbie S. Gipson,Lawrence B. Holzman,Akinlolu O. Ojo,Peter X.-K. Song,Laura Barisoni,Matthew G. Sampson,Jeffrey B. Kopp,Kevin V. Lemley,Peter J. Nelson,Chrysta Lienczewski,Sharon G. Adler,Gerald B. Appel,Daniel C. Cattran,Michael J. Choi,Gabriel Contreras,Katherine MacRae Dell,Fernando C. Fervenza,Keisha L. Gibson,Larry A. Greenbaum,Joel D. Hernandez,Stephen M. Hewitt,Sangeeta Hingorani,Michelle Hladunewich,Marie C. Hogan,Susan L. Hogan,Frederick J. Kaskel,John C. Lieske,Kevin E.C. Meyers,Patrick H. Nachman,Cynthia C. Nast,Alicia M. Neu,Heather N. Reich,John R. Sedor,Christine B. Sethna,Howard Trachtman,Katherine R. Tuttle,Olga Zhdanova,Gaston Zilleruelo,Matthias Kretzler +39 more
TL;DR: Understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies, and Analytical strategies were designed to transform descriptive information to mechanistic disease classification for Nephrotic Syndrome.