G
Giovanna Angelini
Researcher at National Cancer Research Institute
Publications - 41
Citations - 3107
Giovanna Angelini is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Melanoma & Antigen. The author has an hindex of 25, co-authored 41 publications receiving 2898 citations. Previous affiliations of Giovanna Angelini include University of Genoa & Catholic University of the Sacred Heart.
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Journal ArticleDOI
Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome
Jan K. Teller,Claudio Russo,Laura M. Debusk,Giovanna Angelini,Damiano Zaccheo,Francesca Dagna-Bricarelli,Pietro Scartezzini,Stefano Bertolini,David M. A. Mann,Massimo Tabaton,P. Gambetti +10 more
TL;DR: It is reported that soluble Aβ42 is present in the brains of DS–affected subjects aged from 21 gestational weeks to 61 years but it is undetectable in age–matched controls.
Journal ArticleDOI
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
Giovanna Angelini,Stefania Gardella,Massimo Ardy,Maria Rosa Ciriolo,Giuseppe Filomeni,Giovanna Di Trapani,F.M. Clarke,Roberto Sitia,Anna Rubartelli +8 more
TL;DR: It is shown that monocyte-derived human dendritic cells (DCs) release cysteine in the extracellular space during antigen presentation, thus providing a reducing microenvironment that facilitates immune response.
Journal ArticleDOI
NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1.
TL;DR: It is shown that NK cells trigger immature DCs to polarize and secrete interleukin 18 (IL-18), a cytokine lacking a secretory leader sequence, which promotes inflammation and induces DC maturation, thus favoring the onset of the adaptive immune response.
Book ChapterDOI
Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci.
Teodorica L. Bugawan,G T Horn,C M Long,E Mickelson,J A Hansen,G B Ferrara,Giovanna Angelini,Henry A. Erlich +7 more
TL;DR: The observations suggest that the T cell-defined DP specificities are determined by polymorphic residues on the beta-chain, and can be detected using sequence-specific oligonucleotide probes and polymerase chain reaction amplified DNA in a rapid dot-blot format.
Journal ArticleDOI
A combination of a particular HLA-DPβ allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease
Teodorica L. Bugawan,Giovanna Angelini,James W. Larrick,Salvatore Auricchio,Giovanni Battista Ferrara,Henry A. Erlich +5 more
TL;DR: A new DNA-based method of HLA-DP typing is used to analyse the distribution of DPβ alleles in a group of coeliac disease patients and healthy controls and suggests that the polymorphic residues at position 69 and at 56 and 57 may be critical in conferring susceptibility.