Giovanni Barosi

TL;DR: The most clinically relevant UCNs resulted in providing evidence of the benefits and risks of direct oral anticoagulants, improving knowledge of the role of the mutated endothelium in the pathogenesis of thrombosis, improving aspirin dosing regimens in essentialThrombocythemia, and improving antithrombotic management of Ph-neg MPN-associated pregnancy.

TL;DR: Red cell ferritin was measured in normal subjects and patients with iron deficiency and iron overload by means of radioimmunoassays with antibodies to liver (basic) and heart (acidic) ferritins, finding that red cells were found to contain greater amounts of heart‐type than liver‐type ferrit in most of the subjects examined.

TL;DR: Allogeneic transplantation following reduced-intensity conditioning programs, at least in some patients, may induce not only a hematologic response but also a molecular remission, thus supporting the hope of a possible, definitive eradication of the disease.

TL;DR: Overall, these data show for the first time that microvascular endothelial cells in the bone marrow and spleen of patients with primary myelofibrosis show functional and morphologic changes that are associated to the mesenchymal phenotype.

TL;DR: JAK2 ATP-competitive inhibitors or drugs that indirectly inhibit the JAK-STAT pathway, like RAD001, are the new candidates for splenomegaly in MPN-MF, but in spite of their strong rationale, they have shown only a palliative benefit.