Giovanni Barosi

TL;DR: EUMNET, a European research network on myelofibrosis with myeloid metaplasia (MMM), has developed a definition of response by using clinicohematologic, histologic, and cytogenetic criteria, which should help standardize the design and reporting of future clinical studies in MMM.

TL;DR: The pooled RR of studies that tested white blood cell counts in time-dependent models suggested a causative effect of leukocytes in the mechanism that triggers thrombosis, and an investigation on individual patient data in a large collective archive of homogeneous patients is warranted.

TL;DR: A structured expert-panel consensus panel process is used to define RBC-transfusion-dependence and -independence or improvement and it is suggested these definitions may prove useful to persons studying or treating these diseases.

TL;DR: It is found that ECFCs lack the disease-specific markers, which are otherwise present in CFU-ECs, thus reinforcing the concept that the latter belongs to the hematopoietic lineage, and showing that in chronic myeloproliferative disorders the cell that gives rise to circulating ECFC has a distinct origin from the cell of thehematopOietic malignant clone.

TL;DR: Findings indicate that separate entities may exist within the spectrum of dysmyelopoietic syndromes and may be recognized by morphological studies and other simple laboratory means in clinical practice.