Giovanni Barosi

TL;DR: Givinostat was well tolerated and could induce haematological response in most PV and some MF patients and Reverse transcription polymerase chain reaction identified a trend to reduction of the JAK2V617F allele burden.

TL;DR: Among 994 patients with essential thrombocythemia (ET) who were genotyped for the MPLW515L/K mutation, 30 patients carrying the mutation were identified, indicating that MPLw515l/K mutations do not define a distinct phenotype in ET, although some differences depended on the JAK2V617F mutational status of the counterpart.

TL;DR: "Consensus" methodology offers a definition of MMM useful for conducting and reporting clinical studies, and a detailed knowledge of prognostic factors can help to delineate guidelines for addressing patients with allogeneic SCT.

TL;DR: Clinicohematologic, molecular, and histologic response categories were selected to develop a definition of response to treatment in polycythemia vera and essential thrombocythemia (ET) to help standardize the design and reporting of clinical studies.

TL;DR: The rate of major CV events in PMF is comparable with that reported in essential thrombocythemia, and it is increased in aged patients and those with JAK2 V617F mutation and leukocytosis.