Giovanni Perini

TL;DR: The human genome is searched for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation, revealing a substantial but selective increase in complexity compared with Drosophila melanogaster and Caenorhabditis elegans.

TL;DR: A highly sensitive procedure was developed for the identification of the origin of bidirectional DNA synthesis in single-copy replicons of mammalian cells by the absolute quantification, by a competitive PCR procedure in newly synthesized DNA samples, of the abundance of neighboring DNA fragments distributed along a given genomic region.

TL;DR: It is shown that ANKRD26, another gene within the THC2 locus, and neither MASTL nor ACBD5, is mutated in eight unrelated families, and six different AN KRD26 mutations are identified, which were clustered in a highly conserved 19 bp sequence located in the 5' untranslated region.

TL;DR: The isolation and sequencing of L30E-specific cDNAs permitted identification of two genes, one of which encoded a B-type human lamin (analogous to mouse lamin B2) and a coupling between early replication and transcription of genes for S-phase-specific proteins such as lamins.

TL;DR: The results indicate that neurons expressing p75NTR, mostly if expressing also proinflammatory cytokine receptors, might be preferential targets of the cytotoxic action of Aβ in AD, and TNF-α and IL-1β, cytokines produced by Aβ-activated microglia, could potentiate the neurotoxic actionof Aβ mediated by p 75NTR signaling.