G
Giulio Ghersi
Researcher at University of Palermo
Publications - 107
Citations - 2433
Giulio Ghersi is an academic researcher from University of Palermo. The author has contributed to research in topics: Tissue engineering & Proteases. The author has an hindex of 24, co-authored 97 publications receiving 2079 citations. Previous affiliations of Giulio Ghersi include Stony Brook University & Georgetown University Medical Center.
Papers
More filters
Journal ArticleDOI
A Novel Protease-docking Function of Integrin at Invadopodia
Susette C. Mueller,Giulio Ghersi,Giulio Ghersi,Steven K. Akiyama,Qing-Xiang Amy Sang,Linda Howard,Mayra L. Piñeiro-Sánchez,Hirokazu Nakahara,Yunyun Yeh,Wen-Tien Chen,Wen-Tien Chen +10 more
TL;DR: In this article, the authors explore a novel and provocative activity of integrins in docking proteases to sites of invasion, termed invadopodia, and show that α3β1 integrin is a docking protein for seprase to form functional invadodia.
Journal ArticleDOI
Regulation of Fibroblast Migration on Collagenous Matrix by a Cell Surface Peptidase Complex
Giulio Ghersi,Huan Dong,Leslie A. Goldstein,Yunyun Yeh,Lari Häkkinen,Hannu Larjava,Wen-Tien Chen +6 more
TL;DR: Cell surface proteolytic activities, which are non-metalloproteases, seprase and DPPIV, that are responsible for the tissue-invasive phenotype are identified.
Journal ArticleDOI
Molecular cloning of seprase: a serine integral membrane protease from human melanoma
Leslie A. Goldstein,Giulio Ghersi,Mayra L. Piñeiro-Sánchez,Monica Salamone,Yunyun Yeh,Denise Flessate,Wen-Tien Chen +6 more
TL;DR: It is proposed that seprase/FAP alpha and DPPIV represent a new subfamily of serine integral membrane proteases (SIMP) that are not related to the nonclassical serine protease dipeptidyl peptidase IV (DPPIV).
Journal ArticleDOI
The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.
TL;DR: A novel mechanism involving the D PP4 gelatin-binding domain of the DPP4-seprase complex that facilitates the local degradation of the extracellular matrix and the invasion of the endothelial cells into collagenous matrices is identified.
Journal ArticleDOI
Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells
Simona Taverna,Giulio Ghersi,A Ginestra,Salvatrice Rigogliuso,Sonia Pecorella,Giovanna Alaimo,Francesca Saladino,Vincenza Dolo,Patrizia Dell'Era,Antonio Pavan,Giuseppe Pizzolanti,Paolo Mignatti,Marco Presta,Maria Letizia Vittorelli +13 more
TL;DR: It is shown that vesicles represent a major reservoir of FGF-2 and can be released from cells through vesicle shedding, and that F GF-2 is carried inside vESicles.