Giulio Marchesini

TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.

TL;DR: Part correlation analysis confirmed that age, when entered in a multiple regression already containing body weight and estimated liver volume as independent variables, had a significant effect on liver function, whereas no significant independent effect of liver volume was present.

TL;DR: It is concluded that muscle protein catabolism is increased in cirrhotics, possibly as a result of hyperglucagonemia or the reduced insulin/glucagons ratio, which agrees with the clinical observation of a progressive reduction in lean body mass which becomes evident in an advanced stage of the disease.

TL;DR: The functional hepatic nitrogen clearance during amino acid infusion is a measure of liver cell mass and was linearly related to the clinical status, to routine liver function tests and to galactose elimination capacity, a wellestablished, quantitative, liver function measure.