G
Giuseppe Leone
Researcher at Catholic University of the Sacred Heart
Publications - 666
Citations - 23199
Giuseppe Leone is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Transplantation & Myeloid leukemia. The author has an hindex of 74, co-authored 654 publications receiving 21451 citations. Previous affiliations of Giuseppe Leone include University of Milan & International Centre for Genetic Engineering and Biotechnology.
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Journal ArticleDOI
Tolerogenic dendritic cells: cytokine modulation comes of age
TL;DR: Cytokine-modulated TDCs reflect an incomplete or altered status of monocyte differentiation and promote in vitro induction of Treg cells and/or in vivo protection from autoimmune diseases, supporting the concept that DC maturation per se should be considered as a distinguishing feature of immunogenic as opposed to tolerogenic DCs (TDCs).
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DNMT1-interacting RNAs block gene-specific DNA methylation
Annalisa Di Ruscio,Alexander K. Ebralidze,Touati Benoukraf,Giovanni Amabile,Loyal A. Goff,Loyal A. Goff,Loyal A. Goff,Jolyon Terragni,Maria E. Figueroa,Lorena Lobo De Figueiredo Pontes,Meritxell Alberich-Jorda,Meritxell Alberich-Jorda,Pu Zhang,Mengchu Wu,Francesco D'Alo',Ari Melnick,Giuseppe Leone,Konstantin K. Ebralidze,Sriharsa Pradhan,John L. Rinn,John L. Rinn,Daniel G. Tenen,Daniel G. Tenen +22 more
TL;DR: Data is presented demonstrating that active transcription regulates levels of genomic methylation and a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation profile is identified.
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The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation
V. De Stefano,Ida Martinelli,P. M. Mannucci,Katia Paciaroni,Patrizia Chiusolo,I Casorelli,E. Rossi,Giuseppe Leone +7 more
TL;DR: Carriers of both factor V Leiden and the G20210A prothrombin mutation have an increased risk of recurrent deep venous thrombosis after a first episode and are candidates for lifelong anticoagulation.
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Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: A study of 150 families
Ida Martinelli,Ida Martinelli,Ida Martinelli,Pier Mannuccio Mannucci,Pier Mannuccio Mannucci,Pier Mannuccio Mannucci,Valerio De Stefano,Valerio De Stefano,Valerio De Stefano,Emanuela Taioli,Emanuela Taioli,Emanuela Taioli,Valentina Rossi,Valentina Rossi,Valentina Rossi,Francesca Crosti,Francesca Crosti,Francesca Crosti,Katia Paciaroni,Katia Paciaroni,Katia Paciaroni,Giuseppe Leone,Giuseppe Leone,Giuseppe Leone,Elena M. Faioni,Elena M. Faioni,Elena M. Faioni +26 more
TL;DR: Factor V Leiden is associated with a relatively small risk of thrombosis, lower than that for antithrombin, protein C, or protein S deficiency, and individuals with factor VLeiden develop less severeThrombotic manifestations, such as superficial vein thromboembolism.
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Fungal Infections in Recipients of Hematopoietic Stem Cell Transplants: Results of the SEIFEM B-2004 Study—Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne
Livio Pagano,Morena Caira,Annamaria Nosari,M. T. Van Lint,Anna Candoni,Massimo Offidani,Teresa Aloisi,Giuseppe Irrera,Alessandro Bonini,Marco Picardi,Cecilia Caramatti,Rosangela Invernizzi,Daniele Mattei,L. Melillo,C de Waure,Giovanni Reddiconto,Luana Fianchi,Caterina Giovanna Valentini,Corrado Girmenia,Giuseppe Leone,Franco Aversa +20 more
TL;DR: Aspergillus species is the most frequently detected agent in patients who underwent autologous or allogeneic hematopoietic stem cell transplantation (HSCT) at 11 Italian transplantation centers, and aspergillosis is characterized by a high mortality rate.