Giuseppe Verdile

TL;DR: A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD and found the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2 DM and AD.

TL;DR: This protocol describes regular care and maintenance of a zebrafish laboratory and illustrates the protocol for regular housing, feeding, breeding and raising ofZebrafish larvae to help researchers to understand the natural behaviour and optimal conditions of zebra Fish husbandry and hence troubleshoot experimental issues that originate from the fish husbandry conditions.

TL;DR: Current knowledge of Aβ clearance, transport and degradation, and the use of such information in the development of diagnostic tools is summarized and analysed in the context of a potential therapy for AD.

TL;DR: Guinea pigs represent a superior rodent model for analysis of the impact of dietary factors such as cholesterol on the regulation of AD-related genes, and it is concluded that AD- related genes are highly conserved and more similar to human than the rat or mouse.

TL;DR: Clinical and experimental pieces of evidence that link type-2 diabetes with dementia and neurodegenerative diseases such as Alzheimer's disease are reviewed, and underlying mechanisms are discussed.