G
Gloria Brea-Calvo
Researcher at Spanish National Research Council
Publications - 33
Citations - 1119
Gloria Brea-Calvo is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Coenzyme Q – cytochrome c reductase & Mitochondrial respiratory chain. The author has an hindex of 17, co-authored 30 publications receiving 909 citations. Previous affiliations of Gloria Brea-Calvo include Carlos III Health Institute & Pablo de Olavide University.
Papers
More filters
Journal ArticleDOI
Coenzyme Q biosynthesis and its role in the respiratory chain structure.
TL;DR: Some lines of evidence are explored supporting the idea of the interaction of CoQ with the respiratory chain complexes, contributing to their superassembly, including respirasome, and its role in reactive oxygen species production in the mitochondrial inner membrane.
Journal ArticleDOI
Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation.
Rafael Artuch,Gloria Brea-Calvo,Paz Briones,A. Aracil,Marta Galván,Carmen Espinós,Jordi Corral,Victor Volpini,Antonia Ribes,Antoni L. Andreu,Francesc Palau,José Antonio Sánchez-Alcázar,Plácido Navas,Mercè Pineda +13 more
TL;DR: Cerebellar ataxia associated with CoQ deficiency in this case might be allocated in the transprenylation pathway or in the metabolic steps after condensation of 4-hydroxybenzoate and the prenyl side chain of CoQ.
Journal ArticleDOI
Clinical syndromes associated with Coenzyme Q10 deficiency
TL;DR: An updated and comprehensive review of the clinical manifestations associated with each of the pathogenic variants causing primary CoQ deficiencies is presented.
Journal ArticleDOI
COQ4 Mutations Cause a Broad Spectrum of Mitochondrial Disorders Associated with CoQ10 Deficiency
Gloria Brea-Calvo,Tobias B. Haack,Daniela Karall,Akira Ohtake,Federica Invernizzi,Rosalba Carrozzo,Laura S. Kremer,Sabrina Dusi,Christine Fauth,Sabine Scholl-Bürgi,Elisabeth Graf,Uwe Ahting,Nicoletta Resta,Nicola Laforgia,Daniela Verrigni,Yasushi Okazaki,Masakazu Kohda,Diego Martinelli,Peter Freisinger,Tim M. Strom,Thomas Meitinger,Costanza Lamperti,Atilano Lacson,Plácido Navas,Johannes A. Mayr,Enrico Bertini,Kei Murayama,Massimo Zeviani,Holger Prokisch,Daniele Ghezzi +29 more
TL;DR: COQ4 mutations are responsible for early-onset mitochondrial diseases with heterogeneous clinical presentations and associated with CoQ10 deficiency, and the pathogenic role of all identified mutations was experimentally validated in a recombinant yeast model.
Journal ArticleDOI
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy
Sukru Anil Dogan,Raffaele Cerutti,Cristiane Benincá,Gloria Brea-Calvo,Howard T. Jacobs,Massimo Zeviani,Marten Szibor,Marten Szibor,Carlo Viscomi +8 more
TL;DR: Low ROS production in KO-AOX versus KO mice led to impaired AMPK/PGC-1α signaling and PAX7/MYOD-dependent muscle regeneration, blunting compensatory responses and the antioxidant N-acetylcysteine had a similar effect, decreasing the lifespan of KO mice.