Showing papers in "Journal of the Neurological Sciences in 2006"

TL;DR: In this paper, anodal transcranial direct current stimulation (tDCS) is associated with a change in a working memory task performance in patients with Parkinson's disease, and the results showed a significant improvement in working memory as indexed by task accuracy.

TL;DR: There are consistent, albeit moderate, correlations between the progression of cognitive impairment and increasing brain lesion load and brain atrophy in MS, and among clinical predictors, incipient cognitive decline seems to be the major risk factor for further deterioration in the short-term.

TL;DR: It is concluded that Parkinson patients are less inclined than healthy persons to maintain a safe gait and treat all elements of a complex task with equal priority, which in daily life may go at the expense of maintaining balance and lead to falls.

TL;DR: The overall relationship between disease severity and rate of depression (except for off-period related depression) is poor, suggesting that nigrostriatal dysfunction alone is not sufficient to explain depressive symptoms in PD.

TL;DR: Conventional therapies proved effective in Sarin incidents in Japan and both potent toxicity and quick recovery from critical ill conditions were prominent features.

TL;DR: The prevalence of primary brain tumors seems to be higher, whereas the prevalence of intracranial aneurysms is lower than expected, and only a small percentage of the detected abnormalities require urgent medical attention.

TL;DR: Cognitive impairment and vascular risk factors are important predictors of long-term DS and QOL after stroke, and the prognostic value of cognition suggests a reactive component in the development or continuation of long -term DS.

TL;DR: French valid versions of the EMIF-SEP, the short form of the Beck depression inventory and the SF-36 data confirm that fatigue is correlated with disability, but cognitive and psychological dimensions of fatigue remain independent.

TL;DR: Evidence is described which demonstrates that mental conditions also likely play an important role in the pathogenesis of FOG, and a conceptual model that explains how mental conditions may modulate FOG is developed.

TL;DR: The prevalence of open-angle glaucoma (OAG) is high in Japanese patients with AD, suggesting that common factors other than APOE may contribute to the two diseases.

TL;DR: The data indicate that neuronal Golgi fragmentation is an early and probably irreversible lesion in neurodegeneration, caused by a variety of mechanisms, and may "trigger" apoptosis.

TL;DR: These meta-analysis findings indicate that bilateral movements alone or in combination with auxiliary sensory feedback are effective stroke rehabilitation protocols during the sub-acute and chronic phases of recovery.

TL;DR: Dengue patients presenting with encephalopathy had more severe illness and worse outcome compared to acute pure motor weakness and the encephalopathic group 3 died, 2 had partial, 1 poor and 5 complete recovery by 1 month.

TL;DR: Serum-GFAP is increased during the first days after a severe traumatic brain injury and related to clinical outcome, and there is no significant difference in the maximal s- GFAP levels of patients with isolated brain injury in comparison with patients with multiple traumas.

TL;DR: Assessment of the location, composition and connections of the pedunculopontine tegmental nucleus is made to support the hypothesis that it has structural similarities with substantia nigra, suggesting functional similarities exist also.

TL;DR: Since the median MMSE scores decreased from stages 3-6, it is probable that the risk of developing dementia in PD becomes greater as the disease process in the brain progresses.

TL;DR: The results indicate that disability level (EDSS), UEI and cognitive function in MS patients are related with impairment in upper extremity motor function, which contributes to an impairment in physical domain of quality of life.

TL;DR: Results of the follow-up study indicated that both progressive MS subtypes showed a lack of improvement compared to controls on the PASAT and the SDMT, but not on the other tasks of the BRB-N, indicating that performance on tasks requiring multiple abilities concurrently, i.e. visuo-spatial ability and processing speed (SDMT) or working memory andprocessing speed (PASAT), is most likely to decline across time.

TL;DR: These findings are not found in normal controls suggesting that patients with Parkinson's disease are more dependent on dynamic visual cues for gait control than controls.

TL;DR: The results suggested that p62 plays important roles in forming the inclusions and may be associated with the protection of the neurons from degenerative processes involving ubiquitin.

TL;DR: Observations indicate that the blood platelet APP is processed by the same amyloidogenic and non-amyloidsogenic pathways as utilized in brain and that APP processing in AD patients is altered compared to control subjects and may be a useful bio-marker for the diagnosis of AD, the progression of disease and for monitoring drug responses in clinical trials.

TL;DR: Investigating the phase relations between oscillations of BP, MCAFV and NIRS parameters in 38 healthy older adults and 28 patients with unilateral severe obstructive carotid disease finds that Cortical hemodynamic responses to BP oscillations follow specific phase relationships due to cerebral autoregulatory action and circulatory transit times.

TL;DR: The results indicate that specific training is required for improvement of executive functions, while general rehabilitation is not sufficient, and PD-patients might benefit from a short-term cognitive executive function training program that is tailored to the individual patient's needs.

TL;DR: Ischemic stroke subtypes have different risk factors profile, with consequences on pathogenesis and prognosis, and information on determinants of the clinical syndromes may impact on prevention and acute-phase interventions.

TL;DR: The properties of NAs are reviewed and how to recognize the clinical features of NA intoxication, employ the needed drugs properly, and screen out anxious patients who mistakenly believe they have been exposed is reviewed.

TL;DR: In this series, splenomegaly is present in 96% of patients, even in late onset forms during the first years of life, and a disability scale could be useful for monitoring evolution, establishing possible phenotypic correlations and evaluating future therapies.

TL;DR: Frequency of depression and anhedonia as well as motor deficits were significantly reduced during treatment with pramipexole and future studies should investigate specificity of anti-anhedonic and antidepressive properties of pramipingxole.

TL;DR: The potential neuroprotective effect of caffeine and A(2A) receptor antagonists in PD is further substantiated by the demonstration that pharmacological blockade or genetic depletion of the A(1) receptor attenuated dopaminergic neurotoxicity and neurodegeneration in animal models of PD goes beyond PD models and can be extended to a variety of other brain injuries induced by stroke, excitotoxicity and mitochondrial toxins.

TL;DR: It is described that cortical plaques are frequent and widespread, in particular in patients with primary or secondary progressive MS, and certain cortical areas, such as the cingulated gyrus, the insular cortex and the temporobasal cortex, are more affected than others.

TL;DR: Evidence is provided that FXTAS involves marked impairment of executive cognitive abilities, as well as mean verbal and performance IQ scores, which were quite low given the sample's educational level.