G
Gloria Uccello Barretta
Researcher at University of Pisa
Publications - 34
Citations - 508
Gloria Uccello Barretta is an academic researcher from University of Pisa. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Chemistry. The author has an hindex of 12, co-authored 31 publications receiving 424 citations.
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Journal ArticleDOI
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
Paola Infante,Mattia Mori,Romina Alfonsi,Francesca Ghirga,Federica Aiello,Sara Toscano,Cinzia Ingallina,Mariangela Siler,Danilo Cucchi,Agnese Po,Evelina Miele,Davide D'Amico,Gianluca Canettieri,Enrico De Smaele,Elisabetta Ferretti,Isabella Screpanti,Gloria Uccello Barretta,Maurizio Botta,Maurizio Botta,Bruno Botta,Alberto Gulino,Lucia Di Marcotullio +21 more
TL;DR: As a consequence of its robust inhibitory effect on Gli1 activity, Glabrescione B inhibited the growth of Hedgehog‐dependent tumor cells in vitro and in vivo as well as the self‐renewal ability and clonogenicity of tumor‐derived stem cells.
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Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease
Francesco Trotta,Fabrizio Caldera,Roberta Cavalli,Marco Soster,Chiara Riedo,Miriam Biasizzo,Gloria Uccello Barretta,Federica Balzano,Valentina Giovanna Brunella +8 more
TL;DR: The molecularly imprinted nanosponges (MIP-NSs) are a promising alternative for the storage and controlled delivery of L-DOPA and show a slower and more prolonged release profile than the non-imprinted nanosponge structures.
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N - i -Propoxy- N -biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP
Armando Rossello,Elisa Nuti,Paolo Carelli,Elisabetta Orlandini,Marco Macchia,Susanna Nencetti,Maurizio Zandomeneghi,Federica Balzano,Gloria Uccello Barretta,Adriana Albini,Roberto Benelli,Giovanni Cercignani,Gillian Murphy,Aldo Balsamo +13 more
TL;DR: The simultaneous inhibition of these two enzymes yields type C compounds, which are potent antiangiogenic agents, able to block a chemoinvasion model on HUVEC cells in the micromolar range.
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Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling
Rosario Pignatello,Salvatore Guccione,Stefano Forte,Claudia Di Giacomo,Valeria Sorrenti,Luisa Vicari,Gloria Uccello Barretta,Federica Balzano,Giovanni Puglisi +8 more
TL;DR: The conjugates showed the ability of retaining the same inhibitory activity also against the resistant cell subline, against which the parent drug was much less active than against the wild one; the alpha,gamma-bis(hexyl) derivative was the most active term of the series.
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Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one
Salvatore Guccione,Maria N. Modica,Jeanette Longmore,David R. Shaw,Gloria Uccello Barretta,Andrea Santagati,Maria Santagati,Filippo Russo +7 more
TL;DR: 1,6-Diphenyl-pyrazolo [3,4-d]thiazolo[3,2-a]4H-pyrimidin-4-one caused parallel displacement of the dose-response curve to the NK-2 receptor agonist in the guinea pig trachea suggesting it acts as a competitive antagonist.