Agnese Po

TL;DR: Whereas miRNA expression is downregulated in cerebellar neuronal progenitors, it increases alongside differentiation, thereby allowing cell maturation and growth inhibition, and it is suggested that misregulation of specific miRNAs, leading to its aberrant activation, sustain cancer development.

TL;DR: Specific microRNA expression patterns which distinguish medulloblastoma differing in histotypes, in molecular features and in disease‐risk stratification are identified, and misregulated microRNAs expression profiles characterize human medullOBlastomas, and may provide potential targets for novel therapeutic strategies.

TL;DR: This work identifies Numb as a Hedgehog-pathway inhibitor that is downregulated in early GCPs and GCP-derived cancer cells and demonstrates that the Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell differentiation.

TL;DR: It is shown that Nanog is highly expressed in SCs from postnatal cerebellum and medulloblastoma, and acts as a critical mediator of Hh‐driven self‐renewal, which represents a crucial component of an integrated circuitry determining cell fate decision and involved in the maintenance of cancer SCs.

TL;DR: As a consequence of its robust inhibitory effect on Gli1 activity, Glabrescione B inhibited the growth of Hedgehog‐dependent tumor cells in vitro and in vivo as well as the self‐renewal ability and clonogenicity of tumor‐derived stem cells.